(data stored in ACNUC3759 zone)

HOGENOM: RAT4_PE1121

ID   RAT4_PE1121                          STANDARD;      PRT;   439 AA.
AC   RAT4_PE1121; A1L134;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ancient ubiquitous protein 1; (RAT4.PE1121).
GN   Name=Aup1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT4.PE1121.
CC       Rattus norvegicus chromosome 4 RGSC3.4  sequence 1..187126005
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:AUP1_RAT
CC   -!- FUNCTION: May play a role in the translocation of terminally
CC       misfolded proteins from the endoplasmic reticulum lumen to the
CC       cytoplasm and their degradation by the proteasome (By similarity).
CC   -!- SUBUNIT: Identified in a complex that contains SEL1L, OS9,
CC       FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic
CC       tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type III membrane protein; Cytoplasmic side (By similarity).
CC   -!- SIMILARITY: Belongs to the AUP1 family.
CC   -!- SIMILARITY: Contains 1 CUE domain.
CC   -!- GENE_FAMILY: HOG000034232 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000007842;ENSRNOT00000010602;ENSRNOP00000010602.
DR   EMBL; BC127544; - ;
DR   EMBL; CH473957; - ;
DR   UniProtKB/Swiss-Prot; A1L134; -.
DR   EMBL; CH473957; EDL91111.1; -; Genomic_DNA.
DR   EMBL; BC127544; AAI27545.1; -; mRNA.
DR   IPI; IPI00196841; -.
DR   RefSeq; NP_001073368.1; NM_001079899.1.
DR   UniGene; Rn.198163; -.
DR   ProteinModelPortal; A1L134; -.
DR   SMR; A1L134; 294-345.
DR   STRING; A1L134; -.
DR   PRIDE; A1L134; -.
DR   GeneID; 680423; -.
DR   KEGG; rno:680423; -.
DR   NMPDR; fig|10116.3.peg.21684; -.
DR   CTD; 550; -.
DR   RGD; 1591777; Aup1.
DR   eggNOG; roNOG12028; -.
DR   GeneTree; ENSGT00390000016110; -.
DR   InParanoid; A1L134; -.
DR   OrthoDB; EOG47H5Q7; -.
DR   PhylomeDB; A1L134; -.
DR   NextBio; 718673; -.
DR   Genevestigator; A1L134; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008415; F:acyltransferase activity; IEA:InterPro.
DR   InterPro; IPR002123; Acyltransferase.
DR   InterPro; IPR003892; CUE.
DR   Pfam; PF02845; CUE; 1.
DR   SMART; SM00546; CUE; 1.
DR   SMART; SM00563; PlsC; 1.
DR   PROSITE; PS51140; CUE; 1.
DR   HOGENOMDNA; RAT4.PE1121; -.
KW   ENSRNOG00000007842820036002503210000011;
KW   Aup1; AUP1_RAT; BC127544; CH473957;
KW   Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Ubl conjugation pathway.
SQ   SEQUENCE   439 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPKDSAFPGA PAALRRWRRQ RPHFPEAAAM EPPPAPGPER LFDSHRLPSD GFLLLALLLY
     APVGLCLLVL RLFLGLHVFL VSCALPDSVL RRFVVRTMCA VLGLVARQED SGLRDHRVRV
     LISNHVTPFD HNIVNLLTTC STPLLNSPPS FVCWSRGFME MDRRVELVES LKKFCASTRL
     PPTPLLLFPE EEATNGREGL LRFSSWPFSI QDVVQPLTLQ VQRPLVSVTV SDASWVSELL
     WSLFVPFTVY QVRWLHPIRR QLGEENEEFA LRVQQLVAKE LGQIGTRLTP ADKAEHMKRQ
     RHPRLRPQSV QSSFPSPPSP SSDVQLTILA QRVKEVLPHV PLNVIQRDLA RTGCVDLTIT
     NLLEGAVAFM PEDVTEGSQS LPTASAPKFP SSGLVTPQPT ALTFAKSSWA RQESLQERKQ
     ALYEYARRRF RERQAQEAE
//

If you have problems or comments...

PBIL Back to PBIL home page