(data stored in ACNUC3759 zone)

HOGENOM: RAT4_PE1259

ID   RAT4_PE1259                          STANDARD;      PRT;   480 AA.
AC   RAT4_PE1259; Q924Y4; Q8VHY4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Endothelial transcription factor GATA-2;AltName:
DE   Full=GATA-binding protein 2; (RAT4.PE1259).
GN   Name=Gata2;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT4.PE1259.
CC       Rattus norvegicus chromosome 4 RGSC3.4  sequence 1..187126005
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:GATA2_RAT
CC   -!- FUNCTION: Transcriptional activator which regulates endothelin-1
CC       gene expression in endothelial cells. Binds to the consensus
CC       sequence 5'-AGATAG-3' (By similarity). Plays an important role in
CC       the regulation of phagocytosis in alveolar macrophages,
CC       particularly during P.carinii infection.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Contains 2 GATA-type zinc fingers.
CC   -!- GENE_FAMILY: HOG000047701 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000012347;ENSRNOT00000017240;ENSRNOP00000017240.
DR   EMBL; AB102789; - ;
DR   EMBL; AB102790; - ;
DR   EMBL; AF345897; - ;
DR   EMBL; AY032734; - ;
DR   EMBL; BC061745; - ;
DR   EMBL; CH473957; - ;
DR   UniProtKB/Swiss-Prot; Q924Y4; Q8VHY4; -.
DR   EMBL; AY032734; AAK51128.1; -; mRNA.
DR   EMBL; AF345897; AAL57180.1; -; mRNA.
DR   EMBL; BC061745; AAH61745.1; -; mRNA.
DR   IPI; IPI00471624; -.
DR   RefSeq; NP_254277.1; NM_033442.1.
DR   UniGene; Rn.34322; -.
DR   ProteinModelPortal; Q924Y4; -.
DR   SMR; Q924Y4; 290-334, 343-398.
DR   STRING; Q924Y4; -.
DR   PhosphoSite; Q924Y4; -.
DR   Ensembl; ENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347.
DR   GeneID; 25159; -.
DR   KEGG; rno:25159; -.
DR   UCSC; NM_033442; rat.
DR   CTD; 2624; -.
DR   RGD; 2664; Gata2.
DR   eggNOG; roNOG07682; -.
DR   GeneTree; ENSGT00550000074470; -.
DR   InParanoid; Q924Y4; -.
DR   OMA; MEPMAPL; -.
DR   OrthoDB; EOG4S1T85; -.
DR   NextBio; 605625; -.
DR   ArrayExpress; Q924Y4; -.
DR   Genevestigator; Q924Y4; -.
DR   GermOnline; ENSRNOG00000012347; Rattus norvegicus.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006909; P:phagocytosis; IDA:RGD.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IDA:UniProtKB.
DR   InterPro; IPR016374; TF_GATA-1/2/3.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Gene3D; G3DSA:3.30.50.10; Znf_NHR/GATA; 2.
DR   Pfam; PF00320; GATA; 2.
DR   PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
DR   HOGENOMDNA; RAT4.PE1259; -.
KW   ENSRNOG00000012347820036002503210000011;
KW   Gata2; GATA2_RAT; B2DBE1_RAT; AB102789; AB102790; AF345897; AY032734;
KW   CH473957;
KW   Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Phagocytosis; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   480 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY
     ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP
     FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE
     VSPDPSTTGA ASPASPSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP
     ATHHPIPTYP SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
     TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW
     RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC
     MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
//

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