(data stored in ACNUC1829 zone)

HOGENOM: RAT4_PE1729

ID   RAT4_PE1729                          STANDARD;      PRT;   226 AA.
AC   RAT4_PE1729; P40241;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD9 antigen;AltName: CD_antigen=CD9; (RAT4.PE1729).
GN   Name=Cd9;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT4.PE1729.
CC       Rattus norvegicus chromosome 4 RGSC3.4  sequence 1..187126005
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD9_RAT
CC   -!- FUNCTION: Involved in platelet activation and aggregation.
CC       Regulates paranodal junction formation. Involved in cell adhesion,
CC       cell motility and tumor metastasis. Required for sperm-egg fusion
CC       (By similarity).
CC   -!- SUBUNIT: Forms both disulfide-linked homodimers and higher
CC       homooligomers as well as heterooligomers with other members of the
CC       tetraspanin family. Associates with CR2/CD21 and with
CC       PTGFRN/CD9P1. Interacts directly with IGSF8 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in the peripheral nervous system.
CC   -!- PTM: Phosphorylated on tyrosine following B-cell activation (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000019556;ENSRNOT00000026633;ENSRNOP00000026633.
DR   EMBL; BC161804; - ;
DR   EMBL; CH473964; - ;
DR   EMBL; X76489; - ;
DR   UniProtKB/Swiss-Prot; P40241; -.
DR   EMBL; X76489; CAA54027.1; -; mRNA.
DR   IPI; IPI00187902; -.
DR   PIR; I56562; S39262.
DR   RefSeq; NP_444177.1; NM_053018.1.
DR   UniGene; Rn.2091; -.
DR   ProteinModelPortal; P40241; -.
DR   STRING; P40241; -.
DR   Ensembl; ENSRNOT00000026633; ENSRNOP00000026633; ENSRNOG00000019556.
DR   GeneID; 24936; -.
DR   KEGG; rno:24936; -.
DR   CTD; 928; -.
DR   RGD; 2318; Cd9.
DR   eggNOG; roNOG08947; -.
DR   GeneTree; ENSGT00590000082836; -.
DR   InParanoid; P40241; -.
DR   OMA; DICPKKD; -.
DR   OrthoDB; EOG402WT9; -.
DR   PhylomeDB; P40241; -.
DR   NextBio; 604917; -.
DR   ArrayExpress; P40241; -.
DR   Genevestigator; P40241; -.
DR   GermOnline; ENSRNOG00000019556; Rattus norvegicus.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR   GO; GO:0009986; C:cell surface; IDA:RGD.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005178; F:integrin binding; IPI:RGD.
DR   GO; GO:0007420; P:brain development; IEP:RGD.
DR   GO; GO:0007155; P:cell adhesion; ISS:UniProtKB.
DR   GO; GO:0006928; P:cellular component movement; ISS:UniProtKB.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane; ISS:UniProtKB.
DR   GO; GO:0014003; P:oligodendrocyte development; IEP:RGD.
DR   GO; GO:0030913; P:paranodal junction assembly; ISS:UniProtKB.
DR   GO; GO:0009414; P:response to water deprivation; IEP:RGD.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; RAT4.PE1729; -.
KW   ENSRNOG00000019556820036002503210000011;
KW   Cd9; CD9_RAT; B1WBM0_RAT; BC161804; CH473964; X76489;
KW   Cell adhesion; Complete proteome; Direct protein sequencing;
KW   Disulfide bond; Fertilization; Glycoprotein; Lipoprotein; Membrane;
KW   Palmitate; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   226 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPVKGGSKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN HSSFYTGVYI
     LIGAGALMML VGFLGCCGAV QESQCMLGLF FGFLLVIFAI EIAAAVWGYT HKDEVIKELQ
     EFYKDTYQKL RNKDEPQRET LKAIHMALNC CGIAGGVEQF ISDICPKKQV LESFQVKSCP
     DAIDEVFHSK FHIIGAVGIG IAVVMIFGMI FSMILCCAIR RSREMV
//

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