(data stored in ACNUC10243 zone)

HOGENOM: RAT4_PE729

ID   RAT4_PE729                           STANDARD;      PRT;   352 AA.
AC   RAT4_PE729; A7VJC2; A7VJC1; A7VJC3; A7VJC4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Heterogeneous nuclear ribonucleoproteins A2/B1; Short=hnRNP
DE   A2/B1; (RAT4.PE729).
GN   Name=Hnrnpa2b1; Synonyms=Hnrnp, Hnrpa2b1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT4.PE729.
CC       Rattus norvegicus chromosome 4 RGSC3.4  sequence 1..187126005
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA2_RAT
CC   -!- FUNCTION: Involved with pre-mRNA processing. Forms complexes
CC       (ribonucleosomes) with at least 20 other different hnRNP and
CC       heterogeneous nuclear RNA in the nucleous (By similarity).
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Identified in a
CC       mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG,
CC       HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
CC       HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4,
CC       PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
CC       YBX1 and untranslated mRNAs. Interacts with IGF2BP1 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm.
CC       Note=Localized in cytoplasmic mRNP granules containing
CC       untranslated mRNAs. Component of ribonucleosomes (By similarity).
CC       Predominantly nucleoplasmic, however isoform A2 is also found in
CC       the cytoplasm of the squamous epithelia of skin and esophagus. Not
CC       found in the nucleolus. Inhibition of RNA polymerase II
CC       transcription by actinomyin D causes translocation from the
CC       nucleus to the cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC         Comment=Additional isoforms seem to exist;
CC       Name=B1;
CC         IsoId=A7VJC2-1; Sequence=Displayed;
CC       Name=A2;
CC         IsoId=A7VJC2-2; Sequence=VSP_053031;
CC       Name=B0a;
CC         IsoId=A7VJC2-3; Sequence=VSP_053031, VSP_053032;
CC       Name=B0b;
CC         IsoId=A7VJC2-4; Sequence=VSP_053032;
CC   -!- TISSUE SPECIFICITY: In the brain, isoform A2 and isoform B1 are
CC       abundant in large ganglion-type neurons, such as Purkinje cells,
CC       and are less abundant in neighboring glia cells. Isoform A2 is
CC       more abundant than isoform B1 in brain. In testis, isoform A2 and
CC       isoform B1 are present in spermatogonia and spermatocytes, but not
CC       in spermatids or sperm. Isoform A2 is more abundant in the adrenal
CC       medulla than in the cortical cells. Isoform B1 is found in both
CC       adrenal medulla and cortical cells. Isoform A2 is more abundant
CC       than isoform B1 in the adrenal gland. Isoform A2 and isoform B1
CC       are both detected in pancreas and kidney, and at lower levels in
CC       heart and lung. Isoform B1 is more abundant than isoform A2 in
CC       heart, lung and intestine (at protein level). Isoform B0a and
CC       isoform B0b are testis-specific.
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000011175;ENSRNOT00000015152;ENSRNOP00000015152.
DR   EMBL; AB006815; - ;
DR   EMBL; AB006816; - ;
DR   EMBL; AB006817; - ;
DR   EMBL; AB006818; - ;
DR   UniProtKB/Swiss-Prot; A7VJC2; A7VJC1; A7VJC3; A7VJC4; -.
DR   EMBL; AB006815; BAF79675.1; -; mRNA.
DR   EMBL; AB006816; BAF79676.1; -; mRNA.
DR   EMBL; AB006817; BAF79677.1; -; mRNA.
DR   EMBL; AB006818; BAF79678.1; -; mRNA.
DR   IPI; IPI00212969; -.
DR   IPI; IPI00867934; -.
DR   IPI; IPI00923129; -.
DR   IPI; IPI00923135; -.
DR   RefSeq; NP_001098083.1; NM_001104613.1.
DR   UniGene; Rn.4057; -.
DR   ProteinModelPortal; A7VJC2; -.
DR   SMR; A7VJC2; 1-193.
DR   STRING; A7VJC2; -.
DR   PRIDE; A7VJC2; -.
DR   GeneID; 362361; -.
DR   KEGG; rno:362361; -.
DR   CTD; 3181; -.
DR   RGD; 1310403; Hnrnpa2b1.
DR   eggNOG; maNOG08914; -.
DR   GeneTree; ENSGT00540000069937; -.
DR   InParanoid; A7VJC2; -.
DR   OrthoDB; EOG4HQDKF; -.
DR   NextBio; 679650; -.
DR   Genevestigator; A7VJC2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; RAT4.PE729; -.
KW   ENSRNOG00000011175820036002503210000011;
KW   Hnrnpa2b1; LOC499894; ROA2_RAT; AB006815; AB006816; AB006817; AB006818;
KW   Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
KW   Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW   Spliceosome.
SQ   SEQUENCE   352 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     QKTLETVPLE RKKREKEQFR KLFIGGLSFE TTEESLRNYY EQWGKLTDCV VMRDPASKRS
     RGFGFVTFSS MAEVDAAMAA RPHSIDGRVV EPKRAVAREE SGKPGAHVTV KKLFVGGIKE
     DTEEHHLRDY FEEYGKIDTI EIITDRQSGK KRGFGFVTFD DHDPVDKIVL QKYHTINGHN
     AEVRKALSRQ EMQEVQSSRS GRGGNFGFGD SRGGGGNFGP GPGSNFRGGS DGYGSGRGFG
     DGYNGYGGGP GGGNFGGSPG YGGGRGGYGG GGPGYGNQGG GYGGGYDNYG GGNYGSGNYN
     DFGNYNQQPS NYGPMKSGNF GGSRNMGGPY GGGNYGPGGS GGSGGYGGRS RY
//

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