(data stored in ACNUC15468 zone)

HOGENOM: RAT5_PE1805

ID   RAT5_PE1805                          STANDARD;      PRT;   687 AA.
AC   RAT5_PE1805; Q06393; P97709;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel protein ClC-Ka; Short=Chloride channel
DE   Ka;AltName: Full=ClC-K1; (RAT5.PE1805).
GN   Name=Clcnka; Synonyms=Clcnk1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT5.PE1805.
CC       Rattus norvegicus chromosome 5 RGSC3.4  sequence 1..173096209
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCKA_RAT
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels have
CC       several functions including the regulation of cell volume;
CC       membrane potential stabilization, signal transduction and
CC       transepithelial transport. May be important in urinary
CC       concentrating mechanisms.
CC   -!- SUBUNIT: Interacts with BSND.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the kidney.
CC       Expressed strongly in the cortical thick ascending limb and the
CC       distal convoluted tubule, with minor expression in the S3 segment
CC       of the proximal tubule and the cortical collecting tubule.
CC   -!- INDUCTION: Regulated in parallel with BSND under furosemide
CC       treatment. Decreased to half in the inner medulla under furosemide
CC       treatment. In the renal cortex and outer medulla levels were weak
CC       and did not change. Regulation with BSND in inner medulla is
CC       limited to the thin limb; levels in collecting ducts were not
CC       affected by furosemide treatment. During furosemide treatment
CC       selective down-regulation with BSND in thin limb plays a role in
CC       maintaining salt and water homeostasis.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       CLCNKA subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231297 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000009680;ENSRNOT00000013103;ENSRNOP00000013103.
DR   EMBL; BC081761; - ;
DR   EMBL; D13927; - ;
DR   EMBL; Z34291; - ;
DR   UniProtKB/Swiss-Prot; Q06393; P97709; -.
DR   EMBL; D13927; BAA03026.1; -; mRNA.
DR   EMBL; Z34291; CAA84064.1; -; mRNA.
DR   IPI; IPI00192560; -.
DR   PIR; A45483; A45483.
DR   PIR; A57713; A57713.
DR   RefSeq; NP_445779.1; NM_053327.1.
DR   UniGene; Rn.88871; -.
DR   ProteinModelPortal; Q06393; -.
DR   SMR; Q06393; 542-687.
DR   STRING; Q06393; -.
DR   TCDB; 2.A.49.2.4; chloride carrier/channel (ClC) family.
DR   PRIDE; Q06393; -.
DR   GeneID; 79425; -.
DR   KEGG; rno:79425; -.
DR   UCSC; NM_053327; rat.
DR   CTD; 1187; -.
DR   RGD; 68435; Clcnka.
DR   eggNOG; roNOG07385; -.
DR   InParanoid; Q06393; -.
DR   OrthoDB; EOG49W2F2; -.
DR   NextBio; 614772; -.
DR   ArrayExpress; Q06393; -.
DR   Genevestigator; Q06393; -.
DR   GermOnline; ENSRNOG00000009680; Rattus norvegicus.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR   GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
DR   GO; GO:0005887; C:integral to plasma membrane; IDA:RGD.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   GO; GO:0007589; P:body fluid secretion; IEP:RGD.
DR   GO; GO:0051592; P:response to calcium ion; IEP:RGD.
DR   GO; GO:0009268; P:response to pH; IEP:RGD.
DR   GO; GO:0009414; P:response to water deprivation; IEP:RGD.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002250; Cl_channel-K.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 2.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01119; CLCHANNELKDY.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; RAT5.PE1805; -.
KW   ENSRNOG00000009680820036002503210000011;
KW   Clcnka; CLCKA_RAT; Q66HN9_RAT; BC081761; D13927; Z34291;
KW   CBS domain; Chloride; Chloride channel; Complete proteome;
KW   Ion transport; Ionic channel; Membrane; Phosphoprotein;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
SQ   SEQUENCE   687 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEELVGLREG SSGKPVTLQE LWGPCPRIRR GVRRGLEWLK ERLFRVGEDW HFLVALGVLM
     ALISYAMNFA IGRVVRAHKW LYREVGDGHL LRYLSWTVYP VALLSFSSGF SQSISPFSGG
     SGLPELKTML SGVVLEDYLD IKNFGAKVVG LSCTLATGST IFLGKVGPFV HLSVMISAYL
     GRVRAKTIGE TENKAKEIEM LSAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVWNYWRGF
     FAATCGAFMF RLLGVFNSEQ ETITSIYKTR FRVDVPFDLP EIFFFVALGF ICGVLSCAYL
     FCQRTFLCFI KTNRYTSRLL ATSKPSYAAL VALVLASITY PPGVGRFMAS RLSMAEHLHS
     LFDNNSWALM TRNSSPPWPA EPDPQNLWLE WCHPRFTIFG TLAFFLVMKF WMLILATTIP
     MPAGYFMPIF IIGAAIGRLL GEALSVAFPE GIVAGREVNP IMPGGYALAG AAAFSGAVTH
     TISTALLAFE LTGQIVHALP VLMAVLAANA ISQNCQPSFY DGTIMAKKLP YLPWIRGRQI
     GSYPVTVEHF MNCNLTTLAK DTPLEEVVKV VTSTEVSQYP LVETRESQTL VGIVERTHLV
     QALQTQPASW APGQERFPQH VGGRGSITQG PGFEALPQTP VRKAHSLFER LTLQSLFVTS
     RGKAVGSVSW AELKKAISTL INPPAPK
//

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