(data stored in ACNUC15468 zone)

HOGENOM: RAT5_PE1806

ID   RAT5_PE1806                          STANDARD;      PRT;   687 AA.
AC   RAT5_PE1806; P51802;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel protein ClC-Kb; Short=Chloride channel
DE   Kb;AltName: Full=ClC-K2; (RAT5.PE1806).
GN   Name=Clcnkb;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT5.PE1806.
CC       Rattus norvegicus chromosome 5 RGSC3.4  sequence 1..173096209
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCKB_RAT
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels have
CC       several functions including the regulation of cell volume;
CC       membrane potential stabilization, signal transduction and
CC       transepithelial transport. May be important in urinary
CC       concentrating mechanisms.
CC   -!- SUBUNIT: Interacts with BSND.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Golgi apparatus membrane; Multi-pass membrane protein.
CC       Note=Recruited to the plasma membrane in the presence of BSND
CC       protein, whereas remains in the Golgi in its absence.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=ClC-K2L;
CC         IsoId=P51802-1; Sequence=Displayed;
CC       Name=2; Synonyms=ClC-K2S;
CC         IsoId=P51802-2; Sequence=VSP_001049;
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the kidney.
CC       Expressed in all segments of the nephron examined, including the
CC       S2 segment and the glomerulus.
CC   -!- INDUCTION: Expression is consitently weaker in the absence of BSND
CC       protein expression than it is in its presence. The half-life with
CC       BSND protein is much longer than that without it. Rapidly degraded
CC       without BSND protein, exhibiting a very short half-life of less
CC       than 1 hour.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       CLCNKB subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231297 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000009897;ENSRNOT00000013550;ENSRNOP00000013550.
DR   EMBL; D26111; - ;
DR   EMBL; Z30663; - ;
DR   UniProtKB/Swiss-Prot; P51802; -.
DR   EMBL; Z30663; CAA83143.1; -; mRNA.
DR   EMBL; D26111; BAA05106.1; -; mRNA.
DR   EMBL; D26111; BAA05107.1; -; mRNA.
DR   IPI; IPI00206185; -.
DR   IPI; IPI00949027; -.
DR   PIR; B57713; B57713.
DR   RefSeq; NP_775126.1; NM_173103.1.
DR   UniGene; Rn.10339; -.
DR   ProteinModelPortal; P51802; -.
DR   SMR; P51802; 542-687.
DR   STRING; P51802; -.
DR   TCDB; 2.A.49.2.5; chloride carrier/channel (ClC) family.
DR   PRIDE; P51802; -.
DR   GeneID; 79430; -.
DR   KEGG; rno:79430; -.
DR   UCSC; NM_173103; rat.
DR   CTD; 1188; -.
DR   RGD; 628639; Clcnkb.
DR   eggNOG; roNOG07385; -.
DR   GeneTree; ENSGT00550000074179; -.
DR   InParanoid; P51802; -.
DR   OrthoDB; EOG4KD6KM; -.
DR   NextBio; 614791; -.
DR   ArrayExpress; P51802; -.
DR   Genevestigator; P51802; -.
DR   GermOnline; ENSRNOG00000009897; Rattus norvegicus.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   GO; GO:0030321; P:transepithelial chloride transport; NAS:RGD.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002250; Cl_channel-K.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 2.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01119; CLCHANNELKDY.
DR   SMART; SM00116; CBS; 1.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; RAT5.PE1806; -.
KW   ENSRNOG00000009897820036002503210000011;
KW   Clcnkb; CLCKB_RAT; D26111; Z30663;
KW   Alternative splicing; CBS domain; Cell membrane; Chloride;
KW   Chloride channel; Complete proteome; Glycoprotein; Golgi apparatus;
KW   Ion transport; Ionic channel; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
SQ   SEQUENCE   687 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEEIVGLREG SPRKPVPLQE LWRPCPRIRR NIQGSLEWLK ERLFRVGEDW YFLVALGVLM
     ALISYAMNFA IGRVVRAHKW LYREIGDGHL LRYLSWTVYP VALLSFSSGF SQSITPSSGG
     SGIPEVKTIL TGVILEDYLD IKNFGAKVVG LSCTLATGST IFLGKLGPFV HLSVMIAAYL
     GRVRTKTVGE PENKTKEMEL LAAGAAVGVA TVFAAPISGV LFSIEVMSSH FSVWDYWRGF
     FAATCGAFMF HLLAVFNSEQ ETITSIYKTS FPVDIPFDLP EIFFFVALGA ICGILSCGYN
     YCQRTSLFFL KANGFTSKLL ATSKPLYSAL AAVVLASITY PPGVGRFMAS RLSMSEYLET
     LFDNNSWALM TKNSSPPWSA EPDPQNLWLE WCHPQMTVFG TLVFFLVMKF WMLILATTIP
     IPAGYFLPIF VYGAAIGRLF GEVLSLAFPE GIVAGGKVSP IMPGAYALAG AAAFSGAVTH
     TLSTALLAFE VSGQIVHALP VLMAVLAANA ICQSYQPSFY DGTIIVKKLP YLPWIRGRKI
     GSHLVTVGHF MNCTLTTLAK DMPLEEVIKV VISTDVTQYP LVETTESQVL VGIVKRTHLV
     QSLHTDSASW APGQQPCLQD ILANGCPTQP VTLQLSTETS LHETHNLFEL LNLQLLFVTS
     RGRAVGSVSW VELKKAISTL TNPPAPK
//

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