(data stored in ACNUC10243 zone)

HOGENOM: RAT7_PE1942

ID   RAT7_PE1942                          STANDARD;      PRT;   320 AA.
AC   RAT7_PE1942; P04256;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Heterogeneous nuclear ribonucleoprotein A1; Short=hnRNP
DE   A1;AltName: Full=Helix-destabilizing protein; Short=HDP;AltName:
DE   Full=Single-strand RNA-binding protein;AltName: Full=hnRNP core protein
DE   A1; (RAT7.PE1942).
GN   Name=Hnrnpa1; Synonyms=Hnrpa1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT7.PE1942.
CC       Rattus norvegicus chromosome 7 RGSC3.4  sequence 1..143002779
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA1_RAT
CC   -!- FUNCTION: Involved in the packaging of pre-mRNA into hnRNP
CC       particles, transport of poly(A) mRNA from the nucleus to the
CC       cytoplasm and may modulate splice site selection.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Identified in a
CC       mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG,
CC       HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
CC       HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4,
CC       PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
CC       YBX1 and untranslated mRNAs. Interacts with SEPT6 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in
CC       cytoplasmic mRNP granules containing untranslated mRNAs (By
CC       similarity). Shuttles continuously between the nucleus and the
CC       cytoplasm along with mRNA. Component of ribonucleosomes.
CC   -!- PTM: Sumoylated (By similarity).
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000036839;ENSRNOT00000055285;ENSRNOP00000052160.
DR   EMBL; BC062235; - ;
DR   EMBL; BC088150; - ;
DR   EMBL; M12156; - ;
DR   UniProtKB/Swiss-Prot; P04256; -.
DR   EMBL; M12156; AAA41314.1; -; mRNA.
DR   IPI; IPI00421500; -.
DR   PIR; A38304; A38304.
DR   RefSeq; NP_058944.1; NM_017248.1.
DR   UniGene; Rn.25771; -.
DR   ProteinModelPortal; P04256; -.
DR   SMR; P04256; 8-190.
DR   IntAct; P04256; 1.
DR   STRING; P04256; -.
DR   PhosphoSite; P04256; -.
DR   GeneID; 29578; -.
DR   KEGG; rno:29578; -.
DR   UCSC; BC088150; rat.
DR   CTD; 3178; -.
DR   RGD; 69234; Hnrnpa1.
DR   eggNOG; veNOG07502; -.
DR   NextBio; 609678; -.
DR   ArrayExpress; P04256; -.
DR   Genevestigator; P04256; -.
DR   GermOnline; ENSRNOG00000036839; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; ISS:HGNC.
DR   GO; GO:0005654; C:nucleoplasm; ISS:HGNC.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:HGNC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; TAS:RGD.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:HGNC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0051168; P:nuclear export; ISS:HGNC.
DR   GO; GO:0051170; P:nuclear import; ISS:HGNC.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR021662; HnRNPA1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF11627; HnRNPA1; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; RAT7.PE1942; -.
KW   ENSRNOG00000036839820036002503210000011;
KW   Hnrnpa1; RGD1560983; RGD1564866; ROA1_RAT; Q5I0M7_RAT; Q6P6G9_RAT;
KW   BC088150; M12156;
KW   Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
KW   Isopeptide bond; Methylation; mRNA processing; mRNA splicing;
KW   mRNA transport; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding; Spliceosome; Transport;
KW   Ubl conjugation.
SQ   SEQUENCE   320 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
     TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH
     LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA
     LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS
     GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPR
     NQGGYGGSSS SSSYGSGRRF
//

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