(data stored in ACNUC8465 zone)

HOGENOM: RAT7_PE236

ID   RAT7_PE236                           STANDARD;      PRT;   401 AA.
AC   RAT7_PE236; P36506; A0JN15;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 2;
DE   Short=MAP kinase kinase 2; Short=MAPKK 2; EC=2.7.12 2;AltName: Full=ERK
DE   activator kinase 2;AltName: Full=MAPK/ERK kinase 2; Short=MEK 2;
DE   (RAT7.PE236).
GN   Name=Map2k2; Synonyms=Mek2, Mkk2, Prkmk2;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT7.PE236.
CC       Rattus norvegicus chromosome 7 RGSC3.4  sequence 1..143002779
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K2_RAT
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP
CC       kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with MORG1 (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed abundantly in the adult brain and
CC       muscle.
CC   -!- PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for
CC       activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000020005;ENSRNOT00000027272;ENSRNOP00000027272.
DR   EMBL; BC126084; - ;
DR   EMBL; D14592; - ;
DR   EMBL; L14936; - ;
DR   UniProtKB/Swiss-Prot; P36506; A0JN15; -.
DR   EMBL; D14592; BAA03442.1; -; mRNA.
DR   EMBL; L14936; AAA41620.1; -; mRNA.
DR   EMBL; BC126084; AAI26085.1; -; mRNA.
DR   IPI; IPI00231331; -.
DR   PIR; A48081; A48081.
DR   RefSeq; NP_579817.1; NM_133283.1.
DR   UniGene; Rn.82693; -.
DR   ProteinModelPortal; P36506; -.
DR   SMR; P36506; 60-392.
DR   IntAct; P36506; 1.
DR   STRING; P36506; -.
DR   PhosphoSite; P36506; -.
DR   PRIDE; P36506; -.
DR   GeneID; 58960; -.
DR   KEGG; rno:58960; -.
DR   UCSC; NM_133283; rat.
DR   CTD; 5605; -.
DR   RGD; 61888; Map2k2.
DR   eggNOG; roNOG05418; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; P36506; -.
DR   OrthoDB; EOG4SF965; -.
DR   PhylomeDB; P36506; -.
DR   BRENDA; 2.7.12.2; 5301.
DR   Reactome; REACT_106578; Signaling by EGFR.
DR   Reactome; REACT_109781; Immune System.
DR   Reactome; REACT_32280; Signaling by PDGF.
DR   Reactome; REACT_94408; Axon guidance.
DR   Reactome; REACT_96194; Signalling by NGF.
DR   Reactome; REACT_99009; Signaling by Insulin receptor.
DR   NextBio; 611596; -.
DR   ArrayExpress; P36506; -.
DR   Genevestigator; P36506; -.
DR   GermOnline; ENSRNOG00000020005; Rattus norvegicus.
DR   GO; GO:0005938; C:cell cortex; IDA:RGD.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0005625; C:soluble fraction; IDA:RGD.
DR   GO; GO:0005524; F:ATP binding; IDA:RGD.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:RGD.
DR   GO; GO:0005515; F:protein binding; IPI:RGD.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000165; P:MAPKKK cascade; IMP:RGD.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; RAT7.PE236; -.
KW   ENSRNOG00000020005820036002503210000011;
KW   Map2k2; MP2K2_RAT; BC126084; D14592; L14936;
KW   Acetylation; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   401 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLARRKPVLP ALTINPTIAE GPSPTSEGAS EAHLVDLQKK LEELDLDEQQ RKRLEAFLTQ
     KAKVGELKDD DFERISELGA GNGGVVTKAR HRPSGLIMAR KLIHLEIKPA VRNQIIRELQ
     VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEDIL GKVSIAVLRG
     LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ
     GTHYSVQSDI WSMGLSLVEL AIGRYPIPPP DAKELEASFG RPVVDGADGE PHSVSPRPRP
     PGRPISVGHG MDSRPAMAIF ELLDYIVNEP PPKLPSGVFS SDFQEFVNKC LIKNPAERAD
     LKLLTNHAFI KRSEGEDVDF AGWLCRTLRL KQPSTPTRTA V
//

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