(data stored in ACNUC1829 zone)

HOGENOM: RAT7_PE73

ID   RAT7_PE73                            STANDARD;      PRT;   220 AA.
AC   RAT7_PE73; P28648;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=CD63 antigen;AltName: Full=Mast cell antigen AD1;AltName:
DE   CD_antigen=CD63; (RAT7.PE73).
GN   Name=Cd63;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT7.PE73.
CC       Rattus norvegicus chromosome 7 RGSC3.4  sequence 1..143002779
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD63_RAT
CC   -!- FUNCTION: May be involved in the secretory process of mast cells
CC       and may play some role in signal transduction pathways.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane
CC       protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic
CC       vesicle, secretory vesicle membrane; Multi-pass membrane protein.
CC       Note=Secretory granules and plasma membrane of many cultured cell
CC       lines.
CC   -!- TISSUE SPECIFICITY: On mast cells and platelets of rat tissues.
CC       Induced in other cells in culture.
CC   -!- DEVELOPMENTAL STAGE: Increased expression in embryonal tissues.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000007650;ENSRNOT00000010180;ENSRNOP00000010180.
DR   EMBL; AF159104; - ;
DR   EMBL; BC063173; - ;
DR   EMBL; X61654; - ;
DR   UniProtKB/Swiss-Prot; P28648; -.
DR   EMBL; X61654; CAA43835.1; -; mRNA.
DR   EMBL; BC063173; AAH63173.1; -; mRNA.
DR   IPI; IPI00231686; -.
DR   PIR; A46508; A46508.
DR   RefSeq; NP_058821.1; NM_017125.3.
DR   UniGene; Rn.11068; -.
DR   STRING; P28648; -.
DR   PRIDE; P28648; -.
DR   GeneID; 29186; -.
DR   KEGG; rno:29186; -.
DR   CTD; 967; -.
DR   RGD; 62080; Cd63.
DR   eggNOG; roNOG08337; -.
DR   InParanoid; P28648; -.
DR   OrthoDB; EOG4HX51Z; -.
DR   NextBio; 608299; -.
DR   ArrayExpress; P28648; -.
DR   Genevestigator; P28648; -.
DR   GermOnline; ENSRNOG00000007650; Rattus norvegicus.
DR   GO; GO:0016021; C:integral to membrane; TAS:RGD.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR   GO; GO:0043234; C:protein complex; IDA:RGD.
DR   GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032403; F:protein complex binding; IDA:RGD.
DR   GO; GO:0030855; P:epithelial cell differentiation; IMP:RGD.
DR   GO; GO:0010633; P:negative regulation of epithelial cell migration; IMP:RGD.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IMP:RGD.
DR   GO; GO:0045807; P:positive regulation of endocytosis; IMP:RGD.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; RAT7.PE73; -.
KW   ENSRNOG00000007650820036002503210000011;
KW   Cd63; CD63_RAT; Q9QZV0_RAT; AF159104; BC063173; X61654;
KW   Cell membrane; Complete proteome; Cytoplasmic vesicle;
KW   Direct protein sequencing; Glycoprotein; Lysosome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   220 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     LTFSACAVGL IAIGVAVQVV LKQAITHETT AGSLLPVVII AVGAFLFLVA FVGCCGACKE
     NYCLMITFAI FLSLIMLVEV AVAIAGYVFR DQVKSEFSKS FQKQMQNYLT DNKTATILDK
     LQKENKCCGA SNYTDWERIP GMAKDRVPDS CCINITVGCG NDFKESTIHT QGCVETIAAW
     LRKNVLLVAG AALGIAFVEV LGIIFSCCLV KSIRSGYEVM
//

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