(data stored in ACNUC3292 zone)

HOGENOM: RAT7_PE977

ID   RAT7_PE977                           STANDARD;      PRT;   893 AA.
AC   RAT7_PE977; Q5U2X2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Sperm-associated antigen 1;AltName: Full=HSD-3 8;AltName:
DE   Full=Infertility-related sperm protein Spag-1; (RAT7.PE977).
GN   Name=Spag1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT7.PE977.
CC       Rattus norvegicus chromosome 7 RGSC3.4  sequence 1..143002779
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:SPAG1_RAT
CC   -!- FUNCTION: Binds GTP and has GTPase activity (By similarity). Plays
CC       a role in fertilization.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: Testis and sperm.
CC   -!- MISCELLANEOUS: Antibodies against SPAG1 interfere with
CC       fertilization.
CC   -!- SIMILARITY: Contains 8 TPR repeats.
CC   -!- GENE_FAMILY: HOG000293399 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000010078;ENSRNOT00000013801;ENSRNOP00000013801.
DR   EMBL; BC085828; - ;
DR   UniProtKB/Swiss-Prot; Q5U2X2; -.
DR   EMBL; BC085828; AAH85828.1; -; mRNA.
DR   IPI; IPI00360851; -.
DR   RefSeq; NP_001012116.1; NM_001012116.1.
DR   UniGene; Rn.45841; -.
DR   ProteinModelPortal; Q5U2X2; -.
DR   STRING; Q5U2X2; -.
DR   PhosphoSite; Q5U2X2; -.
DR   PRIDE; Q5U2X2; -.
DR   Ensembl; ENSRNOT00000013801; ENSRNOP00000013801; ENSRNOG00000010078.
DR   GeneID; 315033; -.
DR   KEGG; rno:315033; -.
DR   UCSC; NM_001012116; rat.
DR   CTD; 6674; -.
DR   RGD; 1310702; Spag1.
DR   eggNOG; roNOG10630; -.
DR   GeneTree; ENSGT00600000084276; -.
DR   InParanoid; Q5U2X2; -.
DR   OrthoDB; EOG4FFD17; -.
DR   PhylomeDB; Q5U2X2; -.
DR   NextBio; 668504; -.
DR   Genevestigator; Q5U2X2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   InterPro; IPR001440; TPR-1.
DR   InterPro; IPR013026; TPR-contain.
DR   InterPro; IPR011990; TPR-like_helical.
DR   InterPro; IPR019734; TPR_repeat.
DR   Gene3D; G3DSA:1.25.40.10; TPR-like_helical; 3.
DR   Pfam; PF00515; TPR_1; 3.
DR   SMART; SM00028; TPR; 7.
DR   PROSITE; PS50005; TPR; 5.
DR   PROSITE; PS50293; TPR_REGION; 4.
DR   HOGENOMDNA; RAT7.PE977; -.
KW   ENSRNOG00000010078820036002503210000011;
KW   Spag1; SPAG1_RAT; BC085828;
KW   Complete proteome; Cytoplasm; Fertilization; GTP-binding; Hydrolase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat;
KW   TPR repeat.
SQ   SEQUENCE   893 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTAKVKDHPP LWGFGTTKTF KIPIEHLDFK YIENCSDVKQ LEKILCVLRS GEEGYYPELT
     EFCEKRLTGL APRSRALRKD KPAATASSFS AEEWEKIDSD LKSWVSEIKR EENTRHFHDP
     EKHPGVEDPL PPVRGSNSCP RGGKETSSKS KTAKKRIPRD YAEWDKFDVE KECSKIDEDY
     KEKTVINNKA HLSKIETKID TAGLTEKEKN FLANREKGKG NEAFYSGDYE EAVMYYTRSL
     SALPTATAYN NRAQAEIKLQ RWSSALEDCE KALELEPGNI KALLRRATTY KHQNKFLEAV
     DDLRKVLQAE PDNDLAKKTL SEVERELKNS EPASELQTKG KRMVIEEVEN SGDEGGKGDE
     DDHEDDGVDM AAMGNIQKKL MVRSQGGRRS RRARTPMPGA EQQEGQPETG TASTSDNHDL
     EERRAADSPG DLKSRGNELF RGGQFAEAAV QYSGAIAQLE PTGSENADEL SILYSNRAAC
     YLKEGNCRGC IQDCDRALEL QPFAVKPLLR RAMAYETLEQ YRSAYVDYIT VLKIDCRIQL
     ASDSVNRITR ILTELDGPKW RERLPPIPAV PASEPLRVWH PAAETPDQDP CPNSCTPTIT
     DEKMFQALKE EGNQLVKDKN YKDAISKYNE CLKINSKACA IYTNRALCYL KLGQFEEAKL
     DCDKALQIDS KNVKASYRLE LAQKGLENCR ERVADPSQVV LLSPDSSEAA RHLDTKNDTA
     PPSRERERRR IEIQEVDDSS DEEPERPAEA SAVEEGWSAE RAGKIEVCKP RNAYEFGQVL
     STISARKDEE ACAQLLVFTA PQDLPVLLSN KLEGDMLLLI MQSLKSHLVA KDPSLVCKHL
     LYLSKAERFE MMLALTSKDQ KEQMAQLFDD LSDAQADCLT AEDIQALRRQ YVL
//

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