(data stored in ACNUC8465 zone)

HOGENOM: RAT8_PE965

ID   RAT8_PE965                           STANDARD;      PRT;   393 AA.
AC   RAT8_PE965; Q01986; Q5EBD5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 1;
DE   Short=MAP kinase kinase 1; Short=MAPKK 1; EC=2.7.12 2;AltName: Full=ERK
DE   activator kinase 1;AltName: Full=MAPK/ERK kinase 1; Short=MEK 1;
DE   (RAT8.PE965).
GN   Name=Map2k1; Synonyms=Mek1, Prkmk1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT8.PE965.
CC       Rattus norvegicus chromosome 8 RGSC3.4  sequence 1..129041809 annotated
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K1_RAT
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP
CC       kinases. Activates ERK1 and ERK2 MAP kinases.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with MORG1 (By similarity). Found in a complex
CC       with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts with
CC       ARRB2.
CC   -!- PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for
CC       activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000010176;ENSRNOT00000013933;ENSRNOP00000013933.
DR   EMBL; BC089772; - ;
DR   EMBL; D13341; - ;
DR   EMBL; D14591; - ;
DR   EMBL; X62313; - ;
DR   EMBL; Z16415; - ;
DR   UniProtKB/Swiss-Prot; Q01986; Q5EBD5; -.
DR   EMBL; Z16415; CAA78905.1; -; mRNA.
DR   EMBL; D13341; BAA02603.1; -; mRNA.
DR   EMBL; D14591; BAA03441.1; -; mRNA.
DR   EMBL; X62313; CAA44192.1; -; mRNA.
DR   EMBL; BC089772; AAH89772.1; -; mRNA.
DR   IPI; IPI00231247; -.
DR   PIR; JN0840; JN0840.
DR   RefSeq; NP_113831.1; NM_031643.4.
DR   UniGene; Rn.5850; -.
DR   ProteinModelPortal; Q01986; -.
DR   SMR; Q01986; 62-382.
DR   STRING; Q01986; -.
DR   PhosphoSite; Q01986; -.
DR   Ensembl; ENSRNOT00000013933; ENSRNOP00000013933; ENSRNOG00000010176.
DR   GeneID; 170851; -.
DR   KEGG; rno:170851; -.
DR   UCSC; NM_031643; rat.
DR   CTD; 5604; -.
DR   RGD; 70495; Map2k1.
DR   eggNOG; roNOG05418; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q01986; -.
DR   OMA; DIAGWVC; -.
DR   OrthoDB; EOG4SF965; -.
DR   PhylomeDB; Q01986; -.
DR   BRENDA; 2.7.12.2; 5301.
DR   Reactome; REACT_106578; Signaling by EGFR.
DR   Reactome; REACT_109781; Immune System.
DR   Reactome; REACT_32280; Signaling by PDGF.
DR   Reactome; REACT_94408; Axon guidance.
DR   Reactome; REACT_96194; Signalling by NGF.
DR   Reactome; REACT_99009; Signaling by Insulin receptor.
DR   NextBio; 621291; -.
DR   ArrayExpress; Q01986; -.
DR   Genevestigator; Q01986; -.
DR   GermOnline; ENSRNOG00000010176; Rattus norvegicus.
DR   GO; GO:0033267; C:axon part; IDA:RGD.
DR   GO; GO:0005938; C:cell cortex; IDA:RGD.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0032839; C:dendrite cytoplasm; IDA:RGD.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:RGD.
DR   GO; GO:0043204; C:perikaryon; IDA:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR   GO; GO:0005625; C:soluble fraction; IDA:RGD.
DR   GO; GO:0005524; F:ATP binding; IDA:RGD.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:RGD.
DR   GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IDA:RGD.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017016; F:Ras GTPase binding; IPI:RGD.
DR   GO; GO:0000187; P:activation of MAPK activity; IDA:RGD.
DR   GO; GO:0008283; P:cell proliferation; IDA:RGD.
DR   GO; GO:0048313; P:Golgi inheritance; IMP:RGD.
DR   GO; GO:0032402; P:melanosome transport; IDA:RGD.
DR   GO; GO:0007067; P:mitosis; IDA:RGD.
DR   GO; GO:0034111; P:negative regulation of homotypic cell-cell adhesion; IMP:RGD.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IMP:RGD.
DR   GO; GO:0030335; P:positive regulation of cell migration; IMP:RGD.
DR   GO; GO:0032320; P:positive regulation of Ras GTPase activity; IMP:RGD.
DR   GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IMP:MGI.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:RGD.
DR   GO; GO:0003056; P:regulation of vascular smooth muscle contraction; IMP:RGD.
DR   GO; GO:0048678; P:response to axon injury; IMP:RGD.
DR   GO; GO:0051384; P:response to glucocorticoid stimulus; IDA:RGD.
DR   GO; GO:0006979; P:response to oxidative stress; IDA:RGD.
DR   GO; GO:0047496; P:vesicle transport along microtubule; IDA:RGD.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; RAT8.PE965; -.
KW   ENSRNOG00000010176820036002503210000011;
KW   Map2k1; MP2K1_RAT; BC089772; D13341; D14591; X62313; Z16415;
KW   ATP-binding; Complete proteome; Direct protein sequencing; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   393 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV
     GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE
     CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL
     REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY
     SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELLFGCQVE GDAAETPPRP RTPGRPLSSY
     GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF
     IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA ASI
//

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