(data stored in ACNUC25403 zone)

HOGENOM: RAT8_PE99

ID   RAT8_PE99                            STANDARD;      PRT;   426 AA.
AC   RAT8_PE99; P60570;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pannexin-1; (RAT8.PE99).
GN   Name=Panx1; Synonyms=Px1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT8.PE99.
CC       Rattus norvegicus chromosome 8 RGSC3.4  sequence 1..129041809 annotated
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PANX1_RAT
CC   -!- FUNCTION: Structural component of the gap junctions and the
CC       hemichannels. May play a role as a Ca(2+)-leak channel to regulate
CC       ER Ca(2+) homeostasis (By similarity).
CC   -!- SUBUNIT: Homohexamer (By similarity). Forms homomeric or
CC       PANX1/PANX2-heteromeric intercellular channels on coexpression in
CC       paired Xenopus oocytes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential). Cell junction, gap junction (By similarity).
CC       Endoplasmic reticulum membrane; Multi-pass membrane protein (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in the eye, thyroid, prostate,
CC       kidney and liver. Abundantly expressed in the CNS, including
CC       hippocampus, olfactory bulb, cortex, cerebellum and white matter.
CC   -!- SIMILARITY: Belongs to the pannexin family.
CC   -!- GENE_FAMILY: HOG000063721 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000010060;ENSRNOT00000013577;ENSRNOP00000013577.
DR   EMBL; AJ557015; - ;
DR   UniProtKB/Swiss-Prot; P60570; -.
DR   EMBL; AJ557015; CAD89522.1; -; mRNA.
DR   IPI; IPI00210858; -.
DR   RefSeq; NP_955429.1; NM_199397.1.
DR   UniGene; Rn.204521; -.
DR   STRING; P60570; -.
DR   PRIDE; P60570; -.
DR   Ensembl; ENSRNOT00000013577; ENSRNOP00000013577; ENSRNOG00000010060.
DR   GeneID; 315435; -.
DR   KEGG; rno:315435; -.
DR   UCSC; NM_199397; rat.
DR   CTD; 24145; -.
DR   RGD; 735204; Panx1.
DR   eggNOG; roNOG04756; -.
DR   GeneTree; ENSGT00390000009703; -.
DR   OrthoDB; EOG4HT8SW; -.
DR   NextBio; 669246; -.
DR   ArrayExpress; P60570; -.
DR   Genevestigator; P60570; -.
DR   GermOnline; ENSRNOG00000010060; Rattus norvegicus.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; ISS:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0022840; F:leak channel activity; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; IMP:RGD.
DR   GO; GO:0007267; P:cell-cell signaling; IMP:RGD.
DR   GO; GO:0034214; P:protein hexamerization; ISS:UniProtKB.
DR   InterPro; IPR000990; Innexin.
DR   Pfam; PF00876; Innexin; 1.
DR   PROSITE; PS51013; PANNEXIN; 1.
DR   HOGENOMDNA; RAT8.PE99; -.
KW   ENSRNOG00000010060820036002503210000011;
KW   Panx1; PANX1_RAT; AJ557015;
KW   Calcium; Calcium channel; Calcium transport; Cell junction;
KW   Cell membrane; Complete proteome; Endoplasmic reticulum; Gap junction;
KW   Glycoprotein; Ion transport; Ionic channel; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   426 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAIAHLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI SLAFAQEISI
     GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN LPLWLHKFFP YILLLFAILL
     YLPALFWRFA AAPHLCSDLK FIMEELDKVY NRAIKAAKSA RDLDLRDGPG PPGVTENVGQ
     SLWEISESHF KYPIVEQYLK TKKNSSHLIM KYISCRLVTF AVVLLACIYL SYYFSLSSLS
     DEFLCSIKSG VLRNDSTIPD SFQCKLIAVG IFQLLSLINL LVYALLVPVV IYTLFVPFRQ
     KTDVLKVYEI LPTFDVLHFK SEGYNDLSLY NLFLEENISE LKSYKCLKVL ENIKSNGQGI
     DPMLLLTNLG MIKMDVIDGK VPMSLQTKGE DQGSQRMDFK DLDLSSETAA NNGEKNSRQR
     LLNSSC
//

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