(data stored in ACNUC26462 zone)

HOGENOM: RATX_PE1297

ID   RATX_PE1297                          STANDARD;      PRT;   343 AA.
AC   RATX_PE1297; O70150; O08767;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Calcium/calmodulin-dependent protein kinase type 1B;
DE   EC=2.7.11 17;AltName: Full=CaM kinase I beta; Short=CaM kinase IB;
DE   Short=CaM-KI beta; Short=CaMKI-beta;AltName: Full=Pregnancy up-regulated
DE   non-ubiquitously-expressed CaM kinase homolog; (RATX.PE1297).
GN   Name=Pnck;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RATX.PE1297.
CC       Rattus norvegicus chromosome X RGSC3.4  sequence 1..160699376
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCC1B_RAT
CC   -!- FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to
CC       a proposed calcium-triggered signaling cascade. In vitro, isoform
CC       1 and isoform 2 phosphorylate CREB1, SYN1/synapsin I.
CC       Phosphorylates and activates CAMK1.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated by Ca(2+)/calmodulin. Must be
CC       phosphorylated to be maximally active. Activated by CAMKK1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=CamKIbeta2;
CC         IsoId=O70150-1; Sequence=Displayed;
CC       Name=2; Synonyms=CamKIbeta1;
CC         IsoId=O70150-2; Sequence=VSP_012636;
CC   -!- TISSUE SPECIFICITY: Isoform 1 is expressed in liver, heart, lung,
CC       kidney, spleen and testis. Isoform 2 is predominantly expressed in
CC       cerebrum and cerebellum.
CC   -!- PTM: Isoform 1 and isoform 2 are phosphorylated by CAMKK1
CC       (Probable).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
CC       Ser/Thr protein kinase family. CaMK subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000233016 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000017923;ENSRNOT00000024227;ENSRNOP00000024227.
DR   EMBL; AB004267; - ;
DR   EMBL; D86556; - ;
DR   UniProtKB/Swiss-Prot; O70150; O08767; -.
DR   EMBL; D86556; BAA19879.1; -; mRNA.
DR   EMBL; AB004267; BAA28263.1; -; mRNA.
DR   IPI; IPI00195651; -.
DR   IPI; IPI00195716; -.
DR   RefSeq; NP_058971.1; NM_017275.1.
DR   RefSeq; XP_002730347.1; XM_002730301.1.
DR   UniGene; Rn.11178; -.
DR   ProteinModelPortal; O70150; -.
DR   SMR; O70150; 6-310.
DR   STRING; O70150; -.
DR   PhosphoSite; O70150; -.
DR   Ensembl; ENSRNOT00000024227; ENSRNOP00000024227; ENSRNOG00000017923.
DR   GeneID; 100360379; -.
DR   GeneID; 29660; -.
DR   KEGG; rno:100360379; -.
DR   KEGG; rno:29660; -.
DR   UCSC; D86556; rat.
DR   UCSC; NM_017275; rat.
DR   CTD; 139728; -.
DR   RGD; 69249; Pnck.
DR   eggNOG; roNOG12303; -.
DR   GeneTree; ENSGT00600000084207; -.
DR   InParanoid; O70150; -.
DR   OMA; IYESPTH; -.
DR   OrthoDB; EOG4T4CVW; -.
DR   PhylomeDB; O70150; -.
DR   NextBio; 609959; -.
DR   ArrayExpress; O70150; -.
DR   Genevestigator; O70150; -.
DR   GermOnline; ENSRNOG00000017923; Rattus norvegicus.
DR   GO; GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:RGD.
DR   InterPro; IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   PANTHER; PTHR24347; PTHR24347; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; RATX.PE1297; -.
KW   ENSRNOG00000017923820036002503210000011;
KW   Pnck; KCC1B_RAT; AB004267; D86556;
KW   Alternative splicing; ATP-binding; Calcium; Calmodulin-binding;
KW   Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   343 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLLLKKQTED ISSVYEIREK LGSGAFSEVM LAQERGSAHL VALKCIPKKA LRGKEALVEN
     EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV
     LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA
     PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS
     ESAKDFIRHL LERDPQKRFT CQQALQHLWI SGDAALDRDI LGSVSEQIQK NFARTHWKRA
     FNATSFLRHI RKLGQSPEGE EASRQGMTRH SHPGLGTSQS PKW
//

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