(data stored in ACNUC603 zone)

HOGENOM: RATX_PE215

ID   RATX_PE215                           STANDARD;      PRT;   230 AA.
AC   RATX_PE215; Q9JJ46; Q548M8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; EC=5.3.3
DE   5;AltName: Full=Cholestenol Delta-isomerase;AltName:
DE   Full=Delta(8)-Delta(7) sterol isomerase; Short=D8-D7 sterol
DE   isomerase;AltName: Full=Emopamil-binding protein;AltName: Full=Sterol
DE   8-isomerase; (RATX.PE215).
GN   Name=Ebp; Synonyms=Rsi;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RATX.PE215.
CC       Rattus norvegicus chromosome X RGSC3.4  sequence 1..160699376
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:EBP_RAT
CC   -!- FUNCTION: Catalyzes the conversion of Delta(8)-sterols to their
CC       corresponding Delta(7)-isomers (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-
CC       cholest-8-en-3-beta-ol.
CC   -!- PATHWAY: Steroid biosynthesis; cholesterol biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- MISCELLANEOUS: Binds to the phenylalkylamine calcium-ion
CC       antagonist emopamil, an anti-ischemic drug.
CC   -!- SIMILARITY: Belongs to the EBP family.
CC   -!- GENE_FAMILY: HOG000204543 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000004903;ENSRNOT00000007015;ENSRNOP00000007015.
DR   EMBL; AF071501; - ;
DR   EMBL; AF318617; - ;
DR   UniProtKB/Swiss-Prot; Q9JJ46; Q548M8; -.
DR   EMBL; AF071501; AAF74807.1; -; mRNA.
DR   EMBL; AF318617; AAQ14592.1; -; Genomic_DNA.
DR   IPI; IPI00201003; -.
DR   RefSeq; NP_476478.1; NM_057137.1.
DR   UniGene; Rn.19436; -.
DR   STRING; Q9JJ46; -.
DR   PRIDE; Q9JJ46; -.
DR   Ensembl; ENSRNOT00000007015; ENSRNOP00000007015; ENSRNOG00000004903.
DR   GeneID; 117278; -.
DR   KEGG; rno:117278; -.
DR   UCSC; NM_057137; rat.
DR   CTD; 10682; -.
DR   RGD; 620957; Ebp.
DR   eggNOG; roNOG13731; -.
DR   GeneTree; ENSGT00530000063715; -.
DR   InParanoid; Q9JJ46; -.
DR   OMA; PTWHILA; -.
DR   OrthoDB; EOG45490D; -.
DR   PhylomeDB; Q9JJ46; -.
DR   NextBio; 620221; -.
DR   ArrayExpress; Q9JJ46; -.
DR   Genevestigator; Q9JJ46; -.
DR   GermOnline; ENSRNOG00000004903; Rattus norvegicus.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005792; C:microsome; IDA:RGD.
DR   GO; GO:0000247; F:C-8 sterol isomerase activity; IDA:RGD.
DR   GO; GO:0047750; F:cholestenol delta-isomerase activity; IEA:EC.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IDA:RGD.
DR   InterPro; IPR007905; EBP.
DR   PANTHER; PTHR14207; EBP; 1.
DR   Pfam; PF05241; EBP; 1.
DR   HOGENOMDNA; RATX.PE215; -.
KW   ENSRNOG00000004903820036002503210000011;
KW   Ebp; EBP_RAT; AF071501; AF318617;
KW   Acetylation; Cholesterol biosynthesis; Complete proteome;
KW   Endoplasmic reticulum; Isomerase; Lipid synthesis; Membrane;
KW   Reference proteome; Steroid biosynthesis; Sterol biosynthesis;
KW   Transmembrane; Transmembrane helix.
SQ   SEQUENCE   230 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTTNMLPLHP YWPRHLRLDN FVPNDLPTWH ILVGLFSFSG VLIVITWLLS SRVSVVPLGT
     GRRLALCWFA VCTFIHLVIE GWFSFYHEIL LEDQAFLSQL WKEYSKGDSR YILSDGFIVC
     MESVTACLWG PLSLWVVIAF LRHQPFRFVL QLVVSVGQIY GDVLYFLTEL RDGFQHGELG
     HPLYFWFYFV IMNAIWLVIP GILVFDAIKH LTNAQSMLDN KVMKIKSKHN
//

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