(data stored in ACNUC4266 zone)

HOVERGEN: RB33A_HUMAN

ID   RB33A_HUMAN             Reviewed;         237 AA.
AC   Q14088; Q5JUZ6; Q92465;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 2.
DT   03-NOV-2009, entry version 89.
DE   RecName: Full=Ras-related protein Rab-33A;
DE   AltName: Full=Small GTP-binding protein S10;
GN   Name=RAB33A; Synonyms=RABS10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=93345690; PubMed=7688322; DOI=10.1016/0014-5793(93)80957-V;
RA   Koda T., Kakinuma M.;
RT   "Molecular cloning of a cDNA encoding a novel small GTP-binding
RT   protein.";
RL   FEBS Lett. 328:21-24(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT   "cDNA clones of human proteins involved in signal transduction
RT   sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9UI14:RABAC1; NbExp=2; IntAct=EBI-744685, EBI-712367;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed only in lymphoid cell lines.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
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CC   -!- GENE_FAMILY: HBG009351 [ FAMILY / ALN / TREE ]
DR   EMBL; D14889; BAA03606.1; -; mRNA.
DR   EMBL; AF498959; AAM21107.1; -; mRNA.
DR   EMBL; BT007038; AAP35687.1; -; mRNA.
DR   EMBL; AL139234; CAI42781.1; -; Genomic_DNA.
DR   EMBL; BC001157; AAH01157.1; -; mRNA.
DR   EMBL; BC009996; AAH09996.1; -; mRNA.
DR   IPI; IPI00028517; -.
DR   PIR; S35058; S35058.
DR   RefSeq; NP_004785.1; -.
DR   UniGene; Hs.654356; -.
DR   HSSP; P32939; 1KY3.
DR   SMR; Q14088; 35-205.
DR   IntAct; Q14088; 3.
DR   STRING; Q14088; -.
DR   PRIDE; Q14088; -.
DR   Ensembl; ENST00000257017; ENSP00000257017; ENSG00000134594; Homo sapiens.
DR   GeneID; 9363; -.
DR   KEGG; hsa:9363; -.
DR   UCSC; uc004evl.1; human.
DR   CTD; 9363; -.
DR   GeneCards; GC0XP129133; -.
DR   H-InvDB; HIX0017045; -.
DR   HGNC; HGNC:9773; RAB33A.
DR   MIM; 300333; gene.
DR   PharmGKB; PA34124; -.
DR   HOGENOM; Q14088; -.
DR   HOVERGEN; Q14088; -.
DR   OMA; CLTFRFT; -.
DR   NextBio; 35063; -.
DR   ArrayExpress; Q14088; -.
DR   Bgee; Q14088; -.
DR   CleanEx; HS_RAB33A; -.
DR   Genevestigator; Q14088; -.
DR   GermOnline; ENSG00000134594; Homo sapiens.
DR   GO; GO:0009898; C:internal side of plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR003579; GTPase_Rab.
DR   InterPro; IPR013753; Ras.
DR   InterPro; IPR001806; Ras_GTPase.
DR   InterPro; IPR005225; Small_GTP_bd.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q14088.
DR   SWISS-2DPAGE; Q14088.
KW   Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane;
KW   Methylation; Nucleotide-binding; Polymorphism; Prenylation.
FT   DOMAIN        1     32       PRODOM:2005.1:PD914227  2
FT   DOMAIN       35    199       PRODOM:2005.1:PD000015  2217
FT   CHAIN         1    237       Ras-related protein Rab-33A.
FT                                /FTId=PRO_0000121237.
FT   NP_BIND      43     50       GTP (By similarity).
FT   NP_BIND      91     95       GTP (By similarity).
FT   NP_BIND     151    154       GTP (By similarity).
FT   MOD_RES     237    237       Cysteine methyl ester (By similarity).
FT   LIPID       235    235       S-geranylgeranyl cysteine (By
FT                                similarity).
FT   LIPID       237    237       S-geranylgeranyl cysteine (By
FT                                similarity).
FT   VARIANT     102    102       M -> T.
FT                                /FTId=VAR_006849.
SQ   SEQUENCE   237 AA;  26593 MW;  2EE23B8237225F4A CRC64;
     MAQPILGHGS LQPASAAGLA SLELDSSLDQ YVQIRIFKII VIGDSNVGKT CLTFRFCGGT
     FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK SMVEHYYRNV HAVVFVYDVT
     KMTSFTNLKM WIQECNGHAV PPLVPKVLVG NKCDLREQIQ VPSNLALKFA DAHNMLLFET
     SAKDPKESQN VESIFMCLAC RLKAQKSLLY RDAERQQGKV QKLEFPQEAN SKTSCPC
//

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