(data stored in ACNUC4266 zone)

HOVERGEN: RB40B_MOUSE

ID   RB40B_MOUSE             Reviewed;         278 AA.
AC   Q8VHP8;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-NOV-2009, entry version 65.
DE   RecName: Full=Ras-related protein Rab-40B;
DE   AltName: Full=SOCS box-containing protein RAR;
GN   Name=Rab40b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6;
RA   Hilton D.J., Nicola N.A.;
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate-recognition component of a SCF-like
CC       ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex
CC       which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins (By similarity).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the
CC       Elongin BC complex, an adapter module in different E3 ubiquitin
CC       ligase complexes (By similarity).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC   -!- SIMILARITY: Contains 1 SOCS box domain.
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CC   -!- GENE_FAMILY: HBG009351 [ FAMILY / ALN / TREE ]
DR   EMBL; AF425643; AAL60520.1; -; mRNA.
DR   IPI; IPI00876277; -.
DR   RefSeq; NP_631886.2; -.
DR   UniGene; Mm.281639; -.
DR   HSSP; P01112; 1PLL.
DR   STRING; Q8VHP8; -.
DR   PRIDE; Q8VHP8; -.
DR   Ensembl; ENSMUST00000026171; ENSMUSP00000026171; ENSMUSG00000025170; Mus musculus.
DR   Ensembl; ENSMUST00000106107; ENSMUSP00000101713; ENSMUSG00000025170; Mus musculus.
DR   GeneID; 217371; -.
DR   KEGG; mmu:217371; -.
DR   UCSC; uc007mvu.1; mouse.
DR   CTD; 217371; -.
DR   MGI; MGI:2183451; Rab40b.
DR   HOGENOM; Q8VHP8; -.
DR   HOVERGEN; Q8VHP8; -.
DR   OMA; PYGHPAG; -.
DR   NextBio; 375831; -.
DR   ArrayExpress; Q8VHP8; -.
DR   Bgee; Q8VHP8; -.
DR   CleanEx; MM_RAB40B; -.
DR   Genevestigator; Q8VHP8; -.
DR   GermOnline; ENSMUSG00000025170; Mus musculus.
DR   GO; GO:0009898; C:internal side of plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR003579; GTPase_Rab.
DR   InterPro; IPR013753; Ras.
DR   InterPro; IPR001806; Ras_GTPase.
DR   InterPro; IPR005225; Small_GTP_bd.
DR   InterPro; IPR001496; SOCS_C.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00253; SOCS; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q8VHP8.
DR   SWISS-2DPAGE; Q8VHP8.
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW   Palmitate; Prenylation; Ubl conjugation pathway.
FT   DOMAIN       13    177       PRODOM:2005.1:PD000015  2217
FT   DOMAIN      230    278       PRODOM:2005.1:PD586227  6
FT   CHAIN         1    278       Ras-related protein Rab-40B.
FT                                /FTId=PRO_0000121260.
FT   DOMAIN      175    228       SOCS box.
FT   NP_BIND      21     28       GTP (By similarity).
FT   NP_BIND      69     73       GTP (By similarity).
FT   NP_BIND     126    129       GTP (By similarity).
FT   LIPID       270    270       S-palmitoyl cysteine (Potential).
FT   LIPID       275    275       S-geranylgeranyl cysteine (By
FT                                similarity).
SQ   SEQUENCE   278 AA;  31063 MW;  73575AA0367BC3ED CRC64;
     MSSLGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID HKTTTILLDG
     RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV VLVYDIANRW SFDGINRWIK EIDEHAPGVP
     KILVGNRLHL AFKRQVPTEQ AQAYAERLGV TFFEVSPLCN FNITESFTEL ARIVLLRHGM
     DRLWRPSKVL SLQELCCRAV VSCTPGHLVD KLPLPVALRS HLKSFSMASG LNTRMMHGRS
     YSLTANSSHK RNSFRKVRTI RPPQSPPRNC ARNSCKIS
//

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