(data stored in ACNUC22986 zone)

HOVERGEN: RGN_BOVIN

ID   RGN_BOVIN               Reviewed;         299 AA.
AC   Q9TTJ5; Q3ZBB2;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   01-SEP-2009, entry version 50.
DE   RecName: Full=Regucalcin;
DE            Short=RC;
DE   AltName: Full=Senescence marker protein 30;
DE            Short=SMP-30;
GN   Name=RGN; Synonyms=SMP30;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=20351777; PubMed=10891565;
RA   Misawa H., Yamaguchi M.;
RT   "The gene of Ca2+-binding protein regucalcin is highly conserved in
RT   vertebrate species.";
RL   Int. J. Mol. Med. 6:191-196(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calcium-binding protein which regulates Ca(2+) signaling
CC       by regulating Ca(2+)-dependent enzymatic activity in the liver and
CC       kidney. Decrease of RGN leads to the dysregulation of calcium
CC       signaling in the aged liver (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the SMP-30/CGR1 family.
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CC   -!- GENE_FAMILY: HBG004347 [ FAMILY / ALN / TREE ]
DR   EMBL; AB035446; BAA88080.1; -; mRNA.
DR   EMBL; BC103461; AAI03462.1; -; mRNA.
DR   IPI; IPI00709480; -.
DR   RefSeq; NP_776382.1; -.
DR   UniGene; Bt.502; -.
DR   GeneID; 280910; -.
DR   KEGG; bta:280910; -.
DR   CTD; 280910; -.
DR   HOVERGEN; Q9TTJ5; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
DR   GO; GO:0050848; P:regulation of calcium-mediated signaling; ISS:UniProtKB.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008367; Regucalcin.
DR   InterPro; IPR013658; SGL.
DR   InterPro; IPR005511; SMP-30.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   Pfam; PF08450; SGL; 1.
DR   PRINTS; PR01791; REGUCALCIN.
DR   PRINTS; PR01790; SMP30FAMILY.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9TTJ5.
DR   SWISS-2DPAGE; Q9TTJ5.
KW   Calcium; Cytoplasm; Phosphoprotein.
FT   DOMAIN        1    135       PRODOM:2005.1:PD592867  80
FT   DOMAIN      152    174       PRODOM:2005.1:PD792520  22
FT   DOMAIN      175    224       PRODOM:2005.1:PD009905  108
FT   DOMAIN      225    293       PRODOM:2005.1:PD225809  78
FT   CHAIN         1    299       Regucalcin.
FT                                /FTId=PRO_0000173045.
FT   MOD_RES       3      3       Phosphoserine (By similarity).
SQ   SEQUENCE   299 AA;  33308 MW;  4258F7CDB3CCB575 CRC64;
     MSSIKIECVL RENCHCGESP VWEEASNSLL FVDIPAKKVC RWDSLSKQVQ RVTVDAPVSS
     VALRQSGGYV ATVGTKFCAL NWEDQSAVVL ATVDKEKKNN RFNDGKVDPA GRYFAGTMAE
     ETAPAVLERR QGSLYSLFPD HHVEKYFDQV DISNGLDWSM DHKIFYYIDS LSYSVDAFDY
     DLQTGKISNR RSVYKLEKEE QIPDGMCIDV EGKLWVACYN GGRVIRLDPE TGKRLQTVKL
     PVDKTTSCCF GGKDYSEMYV TCARDGLDSK GLLQQPEAGG IFKITGLGVK GIPPYPYTG
//

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