(data stored in ACNUC22986 zone)

HOVERGEN: RGN_CHICK

ID   RGN_CHICK               Reviewed;         299 AA.
AC   Q9I923;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   01-SEP-2009, entry version 30.
DE   RecName: Full=Regucalcin;
DE            Short=RC;
GN   Name=RGN;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=20351777; PubMed=10891565;
RA   Misawa H., Yamaguchi M.;
RT   "The gene of Ca2+-binding protein regucalcin is highly conserved in
RT   vertebrate species.";
RL   Int. J. Mol. Med. 6:191-196(2000).
CC   -!- FUNCTION: Calcium-binding protein which regulates Ca(2+) signaling
CC       by regulating Ca(2+)-dependent enzymatic activity in the liver and
CC       kidney (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the SMP-30/CGR1 family.
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CC   -!- GENE_FAMILY: HBG004347 [ FAMILY / ALN / TREE ]
DR   EMBL; AB037935; BAA90693.1; -; mRNA.
DR   IPI; IPI00574628; -.
DR   RefSeq; NP_990060.1; -.
DR   UniGene; Gga.2861; -.
DR   STRING; Q9I923; -.
DR   Ensembl; ENSGALT00000026988; ENSGALP00000026937; ENSGALG00000016724; Gallus gallus.
DR   Ensembl; ENSGALT00000036601; ENSGALP00000035812; ENSGALG00000016724; Gallus gallus.
DR   GeneID; 395480; -.
DR   KEGG; gga:395480; -.
DR   CTD; 395480; -.
DR   HOGENOM; Q9I923; -.
DR   HOVERGEN; Q9I923; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
DR   GO; GO:0050848; P:regulation of calcium-mediated signaling; ISS:UniProtKB.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008367; Regucalcin.
DR   InterPro; IPR013658; SGL.
DR   InterPro; IPR005511; SMP-30.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   Pfam; PF08450; SGL; 1.
DR   PRINTS; PR01791; REGUCALCIN.
DR   PRINTS; PR01790; SMP30FAMILY.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9I923.
DR   SWISS-2DPAGE; Q9I923.
KW   Calcium; Cytoplasm.
FT   DOMAIN        1    135       PRODOM:2005.1:PD592867  80
FT   DOMAIN      152    174       PRODOM:2005.1:PD792520  22
FT   DOMAIN      175    224       PRODOM:2005.1:PD009905  108
FT   DOMAIN      225    299       PRODOM:2005.1:PD225809  78
FT   CHAIN         1    299       Regucalcin.
FT                                /FTId=PRO_0000287684.
SQ   SEQUENCE   299 AA;  33230 MW;  4754C7571164720E CRC64;
     MSSVKIECVG SDRYRLGESP VWDEKENSLL CVDITGRKVC RWDAASGQVQ ALSVDAPVSS
     VALRKSGDYV ITLGTRFAAL KWKEQLVTTI AQVDRDKANN RFNDGKVDPA GRYFAGTMAE
     EIRPAVLERR QGSLYTLCPD HSVVKHFDQV DISNGLDWSL DHKTFFYIDS LSYSVDAFDY
     DLQTGKIGNR RSVYKLEKEE SIPDGMCIDT EGKLWVACYD GGRVIRLDPE TGKRIQTVKL
     PVDKTTSCCF GGKDYSEMYV TSASDGMDRE WLSRQPQAGG VFKITGLGVK GIPPYPFAG
//

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