(data stored in ACNUC22986 zone)

HOVERGEN: RGN_DANRE

ID   RGN_DANRE               Reviewed;         295 AA.
AC   Q6TLF6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-NOV-2009, entry version 40.
DE   RecName: Full=Regucalcin;
DE            Short=RC;
GN   Name=rgn; ORFNames=zgc:92078;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y.,
RA   Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I.,
RA   Kanki J.P., Liu T.X., Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calcium-binding protein which regulates Ca(2+) signaling
CC       by regulating Ca(2+)-dependent enzymatic activity in the liver and
CC       kidney (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the SMP-30/CGR1 family.
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CC   -!- GENE_FAMILY: HBG004347 [ FAMILY / ALN / TREE ]
DR   EMBL; AY394949; AAQ94576.1; -; mRNA.
DR   EMBL; BC075882; AAH75882.1; -; mRNA.
DR   IPI; IPI00513166; -.
DR   RefSeq; NP_991309.1; -.
DR   RefSeq; XP_001923465.1; -.
DR   UniGene; Dr.85668; -.
DR   Ensembl; ENSDART00000049384; ENSDARP00000049383; ENSDARG00000032200; Danio rerio.
DR   GeneID; 100148250; -.
DR   GeneID; 403070; -.
DR   KEGG; dre:100148250; -.
DR   KEGG; dre:403070; -.
DR   CTD; 403070; -.
DR   ZFIN; ZDB-GENE-040718-68; rgn.
DR   HOGENOM; Q6TLF6; -.
DR   HOVERGEN; Q6TLF6; -.
DR   OMA; CDNPSNP; -.
DR   Bgee; Q6TLF6; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
DR   GO; GO:0050848; P:regulation of calcium-mediated signaling; ISS:UniProtKB.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008367; Regucalcin.
DR   InterPro; IPR013658; SGL.
DR   InterPro; IPR005511; SMP-30.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   Pfam; PF08450; SGL; 1.
DR   PRINTS; PR01791; REGUCALCIN.
DR   PRINTS; PR01790; SMP30FAMILY.
PE   2: Evidence at transcript level;
DR   PRODOM; Q6TLF6.
DR   SWISS-2DPAGE; Q6TLF6.
KW   Calcium; Cytoplasm.
FT   DOMAIN        1    120       PRODOM:2005.1:PD592867  80
FT   DOMAIN      149    178       PRODOM:2005.1:PD792520  22
FT   DOMAIN      179    226       PRODOM:2005.1:PD009905  108
FT   DOMAIN      228    289       PRODOM:2005.1:PD225809  78
FT   CHAIN         1    295       Regucalcin.
FT                                /FTId=PRO_0000287685.
SQ   SEQUENCE   295 AA;  32809 MW;  1FF5C6DD40D6B68D CRC64;
     MSSIKVECVI KEKNEVGESP VWEEKDSSLL YVDITGQKVS RWSSLTKQIE SMNTEKLVGC
     VVPRQAGGYV IAEGTRFAFV DWVKRSITAV AEVNEKPNTR FNDGKVDPAG RFFAGTMSMD
     MKPDVVDAAL YNLQPDHSVV RHFDQVHLSN GLDWSLDHRV FYYIDSLAFM VEAFDYDIQT
     GGLSNRRTVY KMEKDEGIPD GMCIDTEGKL WVACFNGGRV LRIDPQTGKR LQTVKLPAER
     ITSCCFGGKD YSDLYITSAY IGMDAEALAK QPEAGCTFKV TGLGVKGIPP YSYTG
//

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