(data stored in ACNUC22986 zone)

HOVERGEN: RGN_MACFA

ID   RGN_MACFA               Reviewed;         299 AA.
AC   Q2PFX5;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-NOV-2008, entry version 19.
DE   RecName: Full=Regucalcin;
DE            Short=RC;
DE   AltName: Full=Senescence marker protein 30;
DE            Short=SMP-30;
GN   Name=RGN; Synonyms=SMP30; ORFNames=QflA-14884;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RA   Kobayashi M., Tanuma R., Hirata M., Osada N., Kusuda J., Sugano S.,
RA   Hashimoto K.;
RT   "Analysis of gene expression in cynomolgus monkey tissues by macaque
RT   cDNA oligo-chips.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calcium-binding protein which regulates Ca(2+) signaling
CC       by regulating Ca(2+)-dependent enzymatic activity in the liver and
CC       kidney. Decrease of RGN leads to the dysregulation of calcium
CC       signaling in the aged liver (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the SMP-30/CGR1 family.
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CC   -!- GENE_FAMILY: HBG004347 [ FAMILY / ALN / TREE ]
DR   EMBL; AB220462; BAE72995.1; -; mRNA.
DR   HOVERGEN; Q2PFX5; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
DR   GO; GO:0050848; P:regulation of calcium-mediated signaling; ISS:UniProtKB.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008367; Regucalcin.
DR   InterPro; IPR013658; SGL.
DR   InterPro; IPR005511; SMP-30.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   Pfam; PF08450; SGL; 1.
DR   PRINTS; PR01791; REGUCALCIN.
DR   PRINTS; PR01790; SMP30FAMILY.
PE   2: Evidence at transcript level;
DR   PRODOM; Q2PFX5.
DR   SWISS-2DPAGE; Q2PFX5.
KW   Calcium; Cytoplasm; Phosphoprotein.
FT   CHAIN         1    299       Regucalcin.
FT                                /FTId=PRO_0000250476.
FT   MOD_RES       3      3       Phosphoserine (By similarity).
SQ   SEQUENCE   299 AA;  33223 MW;  4BF46578DC00A1BA CRC64;
     MSSIKIECVL PENCRCGESP VWEEASDSLL FVDIPAKKLC RWDSLTKQVQ RVTMDAPVSS
     VALRQSGGYV ATIGTKFCAL NWEEQSAVVL ATVDNDKKNN RFNDGKVDPA GRYFAGTMAE
     ETAPAVLERH QGSLYSLFPD HHVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYSVDAFDY
     DLQTGQISNR RSVYKLEKEE QIPDGMCIDA EGKLWVACYN GGRVIRLDPV TGKRLQTVKL
     PVDKTTSCCF GGKNYSEMYV TCARDGMDPE GLLRQPEAGG IFKITGLGVK GIAPYSYAG
//

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