(data stored in SCRATCH3701 zone)

HOGENOM6: RHOSR_1_PE3647

ID   RHOSR_1_PE3647                       STANDARD;      PRT;   840 AA.
AC   RHOSR_1_PE3647; Q0SAF3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA topoisomerase subunit A; EC=5.99.1 3; (RHOSR_1.PE3647).
GN   Name=gyrA; OrderedLocusNames=RHA1_ro03680;
OS   RHODOCOCCUS JOSTII RHA1.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=101510;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RHOSR_1.PE3647.
CC       Rhodococcus jostii RHA1, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:Q0SAF3_RHOSR
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q0SAF3; -.
DR   EMBL; CP000431; ABG95483.1; -; Genomic_DNA.
DR   RefSeq; YP_703641.1; NC_008268.1.
DR   ProteinModelPortal; Q0SAF3; -.
DR   STRING; Q0SAF3; -.
DR   GeneID; 4221231; -.
DR   GenomeReviews; CP000431_GR; RHA1_ro03680.
DR   KEGG; rha:RHA1_ro03680; -.
DR   eggNOG; COG0188; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   BioCyc; RSP101510:RHA1_RO03680-MONOMER; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; RHOSR_1.PE3647; -.
DR   PRODOM; RHOSR_1_PE3647.
DR   SWISS-2DPAGE; RHOSR_1_PE3647.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   840 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDTTLPPEG PGHDRIEPVD IQQEMQSSYI DYAMSVIVGR ALPDVRDGLK PVHRRVLYAM
     YDNGYRPDRG YVKSARPVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSR
     GNDGAAAMRY TECRLTPLAM EMLREIDHET VDFTPNYDGR TQEPSVLPSR IPNLLINGSG
     GIAVGMATNI PPHNLREVAE AIYWALENWE ADEESTLTAV MERVKGPDFP THGLIVGGQG
     IHDAYTTGRG SVRMRGVVEI EEDAKGRTTI VITELPYQVN PDNLITSIAE QVRDAKIAGI
     SDIHDESSDR AGMRIVVTVK RDAVAKVVLN NLYKHTQLQT SFGCNMLSIV DGVPRTLRLD
     QMIRLYVAHQ VEVIRRRTEY LLRKAEERAH ILRGLVKALD ALDEVIALIR ASQTVDIARA
     GLIELLTVDE IQADAILAMQ LRRLAALERQ KIIDELAEIE REIADLKDIL EKPERQRRIV
     RDELKEIVDK HGDDRRTRII AADGDVADED LIAREDVVVT ITETGYAKRT KTDLYRSQKR
     GGKGVQGAGL KQDDIVSHFF VSSTHDWLLF FTTKGRVYRA KAYELPEASR TARGQHVANL
     LAFQPDERIQ SVIQIKTYED APYLVLATRN GLVKKSKLTD FDSNRSGGIV AINLRGEDEL
     VGAVLCSSDD DLLLVSAQGQ SIRFSATDEA LRPMGRATSG VQGMRFNGDD ELLSLNVVRE
     GTYLLVATSG GYSKRTGMED YPVQGRGGKG VLTIQYDKKR GTLVGALIVN DDDELYAITS
     GGGVIRTAAK QVRKAGRQTK GVRLMNLGEG DTLLAIARNA DEPDEPDDNA ESSGKGAKES
//

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