(data stored in SCRATCH3701 zone)

HOGENOM6: RIPRO1_1_PE198

ID   RIPRO1_1_PE198                       STANDARD;      PRT;   905 AA.
AC   RIPRO1_1_PE198; P41080;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA gyrase subunit A; EC=5.99.1 3; (RIPRO1_1.PE198).
GN   Name=gyrA; OrderedLocusNames=RP206;
OS   RICKETTSIA PROWAZEKII STR. MADRID E.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RIPRO1_1.PE198.
CC       Rickettsia prowazekii str. Madrid E chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:GYRA_RICPR
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings.
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P41080; -.
DR   EMBL; U02931; AAA68146.1; -; Genomic_DNA.
DR   EMBL; AJ235270; CAA14671.1; -; Genomic_DNA.
DR   PIR; H71731; H71731.
DR   RefSeq; NP_220594.1; NC_000963.1.
DR   ProteinModelPortal; P41080; -.
DR   SMR; P41080; 31-512.
DR   GeneID; 883928; -.
DR   GenomeReviews; AJ235269_GR; RP206.
DR   KEGG; rpr:RP206; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   BioCyc; RPRO272947:RP206-MON; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   HAMAP; MF_01897; GyrA; 1; -.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; RIPRO1_1.PE198; -.
DR   PRODOM; RIPRO1_1_PE198.
DR   SWISS-2DPAGE; RIPRO1_1_PE198.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Reference proteome; Topoisomerase.
SQ   SEQUENCE   905 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MIDKYSSNLV PVNIEDEMKV SYLDYAMSVI VSRAIPDVRD GLKPVHRRII YSMYEAGNHA
     SKPYRKSARI VGDVMGKYHP HGDSAIYDSL VRMAQDFSLR LPLVDGQGNF GSMDGDAAAA
     MRYTESRMAK VAHKLVEDID KGTVSFNINY DGSEEEPSVL PAMFPNLLVN GSGGIAVGMA
     TNIPPHNLGE IIDACCLYID NHDIEILDLL EVVKGPDFPT GSMILGISGI RSAYLTGRGS
     IIMRGKAEIE NVGNSRQAII ITEIPYMVNK ARLVEKIAEM VKEKRIEGIS DLRDESNKNG
     IRIFIELKKD VVAEVVLNQI YACTQLQTNF GVIMLALKDG LPKVMNLKEV IAAFVSFREV
     VITNRTIYLL NKARDRAHIL LGLTIAISNI DEIIYIIKAS NDTNLAKQEL MARQWEVLDI
     LPLIKLVDDK VILNERGTLS FTEVQAKAIL EMKLQRLTAM EKEKLEQDLK HLATDIAEYL
     NILASRTRLL EILKEELIKV KEEFASPRLT SIEFGEFDQD IEDLIQREEM VVTVTLGGYI
     KRVPLSSYRS QKRGGKGRSG LSMRDEDITT QVFVGSTHTP MLFFSNIGKV YSLKLYKLPL
     SNPQGKGRPM VNILSLQENE HITNIMPLPE NQDEWDHLNI MFATAKGNIR RSDLLDFKKI
     QSNGKIAIRL DEDDKLIDVK PCKEDEHILL ATKAGKALRF PVESLRIIKS RISDGVRGMK
     LAKEDSVISM TVLKGINSTK EDRDAYLTVP WEKRLEIAKG EEFNLEELGV NLNADSILEM
     ANSEEFILTV TENGFGKRSS AYGYRITDRG GSGIINMDIN DKTGLVVGVM PVKMDDELML
     ITNSGKLIRC KLESVRITGR NTSGVILFKL DDDEKVVSVS LIAETSESEE ASELAEEGLE
     NDVKV
//

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