(data stored in SCRATCH9089 zone)

HOGENOM6: RIPRO1_1_PE65

ID   RIPRO1_1_PE65                        STANDARD;      PRT;   738 AA.
AC   RIPRO1_1_PE65; Q9ZE79;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA topoisomerase 4 subunit A; EC=5.99.1 -;AltName:
DE   Full=Topoisomerase IV subunit A; (RIPRO1_1.PE65).
GN   Name=parC; OrderedLocusNames=RP067;
OS   RICKETTSIA PROWAZEKII STR. MADRID E.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RIPRO1_1.PE65.
CC       Rickettsia prowazekii str. Madrid E chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:PARC_RICPR
CC   -!- FUNCTION: Topoisomerase IV is essential for chromosome
CC       segregation. It relaxes supercoiled DNA. Performs the decatenation
CC       events required during the replication of a circular DNA molecule
CC       (By similarity).
CC   -!- SUBUNIT: Composed of two subunits: ParC and ParE (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- GENE_FAMILY: HOG000076277 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q9ZE79; -.
DR   EMBL; AJ235270; CAA14538.1; -; Genomic_DNA.
DR   PIR; C71715; C71715.
DR   RefSeq; NP_220461.1; NC_000963.1.
DR   ProteinModelPortal; Q9ZE79; -.
DR   GeneID; 883632; -.
DR   GenomeReviews; AJ235269_GR; RP067.
DR   KEGG; rpr:RP067; -.
DR   OMA; HNAAELC; -.
DR   ProtClustDB; PRK05561; -.
DR   BioCyc; RPRO272947:RP067-MON; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   InterPro; IPR005742; TopoIV_A_Gneg.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 2.
DR   Pfam; PF03989; DNA_gyraseA_C; 3.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01062; ParC_Gneg; 1.
DR   HOGENOMDNA; RIPRO1_1.PE65; -.
DR   PRODOM; RIPRO1_1_PE65.
DR   SWISS-2DPAGE; RIPRO1_1_PE65.
KW   DNA topoisomerase IV subunit A;
KW   Cell membrane; Complete proteome; DNA-binding; Isomerase; Membrane;
KW   Reference proteome; Topoisomerase.
SQ   SEQUENCE   738 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKEAKIENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM LQLRLEPNSG
     YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL IDGQGNFGSI DGDNAAAMRY
     TESRMTEICM LLMEDIDKDT VDFRSTYDDS DLEPVIMPAS FPNLLANGSE GIAVGMATNI
     PPHNLHELCD ALLYLIDNPQ AGINDIMNFI KGPDFPTGGI IIDKAEVINA AYTTGRGSFR
     VRSRWEKEEL SYGTYQIVVT EIPYQIQKSK LIEQIAILLK DKKIPLISSI RDESTDIIRV
     VIEPRDRSCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNILEIL QEFLVHRKNI
     IIRRSTYLLN KIKQRLEILK VLRIVYLNLD EIIEIIREED EPKTIIMERF KISAIQVEVI
     LNTRLRSLQK LEEHAIIDEH SNLQKQQAIL EKILKNHKEL WQIVKKEIKA VQTKFGLNTI
     IGARRTSFEE VDLTNQVVDI TAFITKEPIT IICSKMGWVR SLKGHNTDLS TIKYKEGDTE
     KFIIEAYTTD KILIISSKGR FFTLLADNIS KGKGTGGVSI KLLVDIGNND ITNILVYKPN
     QLLLLASSIG KGFLVNSNEV IAQTKTGKQI MNIPEGYSCI ACLPVNGDSI ACIGESRRLL
     VFNIDEIPEM KKGQGVVLQR FKNAKLLDIK IFNKQDGLSW NDGTKIQLEK NIVAFLGKRG
     GFGTFPPIGF PKNNRFSP
//

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