(data stored in SCRATCH3701 zone)

HOGENOM6: ROTDC_1_PE896

ID   ROTDC_1_PE896                        STANDARD;      PRT;   879 AA.
AC   ROTDC_1_PE896; E3H315;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA topoisomerase (ROTDC_1.PE896) (ATP-hydrolyzing) subunit
DE   A; EC=5.99.1 3; .
GN   Name=gyrA; OrderedLocusNames=HMPREF0733_10897;
OS   ROTHIA DENTOCARIOSA ATCC 17931.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Micrococcineae; Micrococcaceae; Rothia.
OX   NCBI_TaxID=762948;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ROTDC_1.PE896.
CC       Rothia dentocariosa ATCC 17931 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:E3H315_ROTDC
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E3H315; -.
DR   EMBL; CP002280; ADP40354.1; -; Genomic_DNA.
DR   RefSeq; YP_003983788.1; NC_014643.1.
DR   GeneID; 9902165; -.
DR   GenomeReviews; CP002280_GR; HMPREF0733_10897.
DR   KEGG; rdn:HMPREF0733_10897; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; ROTDC_1.PE896; -.
DR   PRODOM; ROTDC_1_PE896.
DR   SWISS-2DPAGE; ROTDC_1_PE896.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   879 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSEENQSENP DIEVTTNSGE IVLDDPHGHI EQVDLQTEMQ RSYLDYAMAV IIGRALPDVR
     DGLKPVHRRV IYAMYDGGYR PDRAFNKCAR VVGDVMGQFH PHGDSAIYDT LVRLIQSWIM
     RYPLALGQGN FGSPGNDGAA APRYTETKMA PIALEMVRDI NEDTVDFQPN YDGKSLEPTV
     LPARIPNLLV NGSSGIAVGM ATNIPPHNLR EVAAGVEWFL KNPNATNEEL LSALMERIKG
     PDFPTGATIL GTKGIEDAYR TGRGSITMRA VVNVEEIHGR TCLVVTELPY QANPDNLAIK
     IADLIKEGKV TGISDLRDET SGRTGQRLVI VLKRDAVPKV VLNNLYKHTQ LQENFSANML
     AIVDGVPRTL SLDAFIRHWV NHQMDVIVRR TRYRLRQAEE EAHILRGLLK ALDALDEVIA
     LIRRSPTADE ARSALMDFLD IDEAQAQAIL NMQLRRLAAL ERQKIQDRHD ELQRLISEYN
     AIIASEDRQR EIISEELGEI VNRYGDDRRT EILRGFNGDM SMEDLIPEEE VVVTITRGGY
     IKRTRSDQYR SQHRGGKGIR GAQLRGDDVV EHFFVTTTHS WILFFTNLGR VYRTKGYELQ
     EAGRDAKGQH LANLLEFQPD EHIAQVMDLK TYEDAEYLVL ATKGGLVKKS RLSDYDTNRT
     AGLIAINLRD DDEVVSAFLV SPEDDILLIS RNGMSLRFHA NNESLRPMGR STSGVTGMKF
     RDGDELISAQ VVIPESFVFV VTEGGYAKRT HVEGYRVQGR NGFGIKVAKL VEGRGALVGG
     LIVSENDEVL VVMQSGKVVR TNVSEVPAKG RDTMGVIFAK PGKGDSIIGI ARNQDRQLDE
     QKEDDAEVEA TEESVINSEV VDTQENTPTT ASTDVDGGN
//

If you have problems or comments...

PBIL Back to PBIL home page