(data stored in ACNUC25865 zone)

HOVERGEN: RS4Y1_HUMAN

ID   RS4Y1_HUMAN             Reviewed;         263 AA.
AC   P22090; A8K9V4;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-NOV-2009, entry version 92.
DE   RecName: Full=40S ribosomal protein S4, Y isoform 1;
GN   Name=RPS4Y1; Synonyms=RPS4Y; ORFNames=PRO2646;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=91084849; PubMed=2124517; DOI=10.1016/0092-8674(90)90416-C;
RA   Fisher E.M.C., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A.,
RA   Lawrence J.B., Willard H.F., Bieber F.R., Page D.C.;
RT   "Homologous ribosomal protein genes on the human X and Y chromosomes:
RT   escape from X inactivation and possible implications for Turner
RT   syndrome.";
RL   Cell 63:1205-1218(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zuo L., Baybayan P., Kuang W.-J., Brown L., Page D., Chen E.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fetal liver;
RA   Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J.,
RA   Liu M., He F.;
RT   "Functional prediction of the coding sequences of 121 new genes
RT   deduced by analysis of cDNA clones from human fetal liver.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- MISCELLANEOUS: This isoform is encoded on the Y chromosome.
CC   -!- SIMILARITY: Belongs to the ribosomal protein S4e family.
CC   -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
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CC   -!- GENE_FAMILY: HBG000935 [ FAMILY / ALN / TREE ]
DR   EMBL; M58459; AAA63256.1; -; mRNA.
DR   EMBL; AF041427; AAB96967.1; -; Genomic_DNA.
DR   EMBL; AF116711; AAF71131.1; -; mRNA.
DR   EMBL; AK292819; BAF85508.1; -; mRNA.
DR   EMBL; CH471115; EAX02771.1; -; Genomic_DNA.
DR   EMBL; BC010286; AAH10286.1; -; mRNA.
DR   IPI; IPI00302740; -.
DR   PIR; A36338; R3HU4Y.
DR   RefSeq; NP_000999.1; -.
DR   UniGene; Hs.282376; -.
DR   STRING; P22090; -.
DR   PhosphoSite; P22090; -.
DR   PRIDE; P22090; -.
DR   Ensembl; ENST00000250784; ENSP00000250784; ENSG00000129824; Homo sapiens.
DR   Ensembl; ENST00000430575; ENSP00000415317; ENSG00000129824; Homo sapiens.
DR   GeneID; 6192; -.
DR   KEGG; hsa:6192; -.
DR   NMPDR; fig|9606.3.peg.33731; -.
DR   UCSC; uc004fqi.1; human.
DR   CTD; 6192; -.
DR   GeneCards; GC0YP002769; -.
DR   GeneCards; GC0YP002770; -.
DR   H-InvDB; HIX0017179; -.
DR   H-InvDB; HIX0064539; -.
DR   HGNC; HGNC:10425; RPS4Y1.
DR   HPA; HPA000857; -.
DR   MIM; 470000; gene.
DR   PharmGKB; PA34840; -.
DR   HOGENOM; P22090; -.
DR   HOVERGEN; P22090; -.
DR   OMA; RDKRLAT; -.
DR   Reactome; REACT_17015; Metabolism of proteins.
DR   Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR   Reactome; REACT_6167; Influenza Infection.
DR   Reactome; REACT_71; Gene Expression.
DR   ArrayExpress; P22090; -.
DR   Bgee; P22090; -.
DR   CleanEx; HS_RPS4Y1; -.
DR   Genevestigator; P22090; -.
DR   GermOnline; ENSG00000129824; Homo sapiens.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; NAS:UniProtKB.
DR   GO; GO:0005844; C:polysome; IDA:UniProtKB.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IMP:UniProtKB.
DR   GO; GO:0007275; P:multicellular organismal development; IMP:UniProtKB.
DR   GO; GO:0006414; P:translational elongation; EXP:Reactome.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR000876; Ribosomal_S4e.
DR   InterPro; IPR013845; Ribosomal_S4e_central.
DR   InterPro; IPR013843; Ribosomal_S4e_N.
DR   InterPro; IPR018199; Ribosomal_S4e_N_CS.
DR   InterPro; IPR002942; S4_RNA_bd.
DR   PANTHER; PTHR11581; Ribosomal_S4E; 1.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF00900; Ribosomal_S4e; 1.
DR   Pfam; PF08071; RS4NT; 1.
DR   Pfam; PF01479; S4; 1.
DR   PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR   ProDom; PD002667; Ribosomal_S4E; 1.
DR   SMART; SM00363; S4; 1.
DR   PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR   PROSITE; PS50889; S4; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P22090.
DR   SWISS-2DPAGE; P22090.
KW   Complete proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW   rRNA-binding.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    263       40S ribosomal protein S4, Y isoform 1.
FT                                /FTId=PRO_0000130812.
FT   DOMAIN       42    104       S4 RNA-binding.
SQ   SEQUENCE   263 AA;  29456 MW;  3B5D6F1ECFCB120A CRC64;
     MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE
     VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITVEEAK
     YKLCKVRKIT VGVKGIPHLV THDARTIRYP DPVIKVNDTV QIDLGTGKII NFIKFDTGNL
     CMVIGGANLG RVGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR
     GKGIRLTVAE ERDKRLATKQ SSG
//

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