(data stored in ACNUC25865 zone)

HOVERGEN: RS4Y2_HUMAN

ID   RS4Y2_HUMAN             Reviewed;         263 AA.
AC   Q8TD47; A6NIR6;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-NOV-2009, entry version 58.
DE   RecName: Full=40S ribosomal protein S4, Y isoform 2;
GN   Name=RPS4Y2; Synonyms=RPS4Y2P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA / MRNA].
RX   MEDLINE=22699787; PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S.,
RA   Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T.,
RA   Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G.,
RA   Fulton L., Fulton R., Graves T.A., Hou S.-F., Latrielle P.,
RA   Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W.,
RA   Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K.,
RA   Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H.,
RA   Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of
RT   discrete sequence classes.";
RL   Nature 423:825-837(2003).
RN   [2]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-22, AND MASS SPECTROMETRY.
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,
RA   Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
CC   -!- MISCELLANEOUS: This isoform is encoded on the Y chromosome.
CC   -!- SIMILARITY: Belongs to the ribosomal protein S4e family.
CC   -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
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CC   -!- GENE_FAMILY: HBG000935 [ FAMILY / ALN / TREE ]
DR   EMBL; AC009494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF497481; AAM18074.1; -; mRNA.
DR   IPI; IPI00219894; -.
DR   RefSeq; NP_001034656.1; -.
DR   UniGene; Hs.367761; -.
DR   STRING; Q8TD47; -.
DR   PhosphoSite; Q8TD47; -.
DR   PRIDE; Q8TD47; -.
DR   Ensembl; ENST00000288666; ENSP00000288666; ENSG00000157828; Homo sapiens.
DR   GeneID; 140032; -.
DR   KEGG; hsa:140032; -.
DR   NMPDR; fig|9606.3.peg.33816; -.
DR   UCSC; uc004fum.1; human.
DR   CTD; 140032; -.
DR   GeneCards; GC0YP021256; -.
DR   H-InvDB; HIX0056683; -.
DR   HGNC; HGNC:18501; RPS4Y2.
DR   HPA; HPA000857; -.
DR   MIM; 400030; gene.
DR   HOGENOM; Q8TD47; -.
DR   HOVERGEN; Q8TD47; -.
DR   OMA; NSFATRI; -.
DR   NextBio; 84063; -.
DR   Genevestigator; Q8TD47; -.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR000876; Ribosomal_S4e.
DR   InterPro; IPR013845; Ribosomal_S4e_central.
DR   InterPro; IPR013843; Ribosomal_S4e_N.
DR   InterPro; IPR018199; Ribosomal_S4e_N_CS.
DR   InterPro; IPR002942; S4_RNA_bd.
DR   PANTHER; PTHR11581; Ribosomal_S4E; 1.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF00900; Ribosomal_S4e; 1.
DR   Pfam; PF08071; RS4NT; 1.
DR   PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR   ProDom; PD002667; Ribosomal_S4E; 1.
DR   SMART; SM00739; KOW; 1.
DR   SMART; SM00363; S4; 1.
DR   PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR   PROSITE; PS50889; S4; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8TD47.
DR   SWISS-2DPAGE; Q8TD47.
KW   Acetylation; Complete proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    263       40S ribosomal protein S4, Y isoform 2.
FT                                /FTId=PRO_0000130818.
FT   DOMAIN       42    104       S4 RNA-binding.
FT   MOD_RES      22     22       N6-acetyllysine.
SQ   SEQUENCE   263 AA;  29295 MW;  7044C5C97361E3D0 CRC64;
     MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE
     VKKICMQHFL KIDGKVRVDI TYPAGFIDVI SIEKTGEHFR LVYNTKGCFA VHRITVEEAK
     YKLCKVRKIT VGTKGIPHLV THDARTIRYP DPLIKVNDTV QIDLGTGKIT SFIKFDTGNV
     CMVIAGANLG RVGVITNRER HPGSCDVVHV KDANGNSFAT RISNIFVIGN GNKPWISLPR
     GKGIRLTIAE ERDKRLAAKQ SSG
//

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