(data stored in ACNUC7421 zone)

HOGENOM: RUPOM1_1_PE10

ID   RUPOM1_1_PE10                        STANDARD;      PRT;   187 AA.
AC   RUPOM1_1_PE10; Q5LWF4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein grpE;AltName: Full=HSP-70 cofactor;
DE   (RUPOM1_1.PE10).
GN   Name=grpE; OrderedLocusNames=SPO0010;
OS   RUEGERIA POMEROYI DSS-3.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Ruegeria.
OX   NCBI_TaxID=246200;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RUPOM1_1.PE10.
CC       Ruegeria pomeroyi DSS-3 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:Q5LWF4_SILPO
CC   -!- FUNCTION: Participates actively in the response to hyperosmotic
CC       and heat shock by preventing the aggregation of stress-denatured
CC       proteins, in association with dnaK and grpE. It is the nucleotide
CC       exchange factor for dnaK and may function as a thermosensor.
CC       Unfolded proteins bind initially to dnaJ; upon interaction with
CC       the dnaJ-bound protein, dnaK hydrolyzes its bound ATP, resulting
CC       in the formation of a stable complex. GrpE releases ADP from dnaK;
CC       ATP binding to dnaK triggers the release of the substrate protein,
CC       thus completing the reaction cycle. Several rounds of ATP-
CC       dependent interactions between dnaJ, dnaK and grpE are required
CC       for fully efficient folding (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the grpE family.
CC   -!- GENE_FAMILY: HOG000252083 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q5LWF4; -.
DR   EMBL; CP000031; AAV93341.1; -; Genomic_DNA.
DR   RefSeq; YP_165283.1; NC_003911.11.
DR   ProteinModelPortal; Q5LWF4; -.
DR   GeneID; 3195554; -.
DR   GenomeReviews; CP000031_GR; SPO0010.
DR   KEGG; sil:SPO0010; -.
DR   NMPDR; fig|246200.3.peg.499; -.
DR   OMA; NVPFNPE; -.
DR   ProtClustDB; CLSK933110; -.
DR   BioCyc; RPOM246200:SPO_0010-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0051087; F:chaperone binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0006950; P:response to stress; IEA:UniProtKB-KW.
DR   HAMAP; MF_01151; GrpE; 1; -.
DR   InterPro; IPR000740; GrpE.
DR   InterPro; IPR013805; GrpE_coiled_coil.
DR   InterPro; IPR009012; GrpE_head.
DR   Gene3D; G3DSA:3.90.20.20; GrpE_coiled_coil; 1.
DR   Gene3D; G3DSA:2.30.22.10; GrpE_head; 1.
DR   PANTHER; PTHR21237; GrpE; 1.
DR   Pfam; PF01025; GrpE; 1.
DR   PRINTS; PR00773; GRPEPROTEIN.
DR   SUPFAM; SSF51064; GrpE_head; 1.
DR   PROSITE; PS01071; GRPE; 1.
DR   HOGENOMDNA; RUPOM1_1.PE10; -.
KW   co-chaperone GrpE;
KW   Chaperone; Complete proteome; Cytoplasm; Stress response.
SQ   SEQUENCE   187 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAKPNNEEFL DDIATAEAEE LAEEMAEISD EAAELDTLRA ERDAFKDKFM RALADAENVR
     KRGERARREA EQYGGSKLAR DMLPVYDNMK RALETVTDEQ RAVSGALIEG IELTMRALLD
     VFGKHGIQVL SPQVGDRFDP QMHEAMFEAP VPGTKAGDII QVSAEGFMLH DRLLRPAQVG
     VSSMPAG
//

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