(data stored in SCRATCH3701 zone)

HOGENOM6: SACEN_1_PE7

ID   SACEN_1_PE7                          STANDARD;      PRT;   831 AA.
AC   SACEN_1_PE7; A4F5N8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; EC=5.99.1 3; (SACEN_1.PE7).
GN   Name=gyrA; OrderedLocusNames=SACE_0009;
OS   SACCHAROPOLYSPORA ERYTHRAEA NRRL 2338.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Pseudonocardineae; Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SACEN_1.PE7.
CC       Saccharopolyspora erythraea NRRL 2338 chromosome, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:A4F5N8_SACEN
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A4F5N8; -.
DR   EMBL; AM420293; CAL99362.1; -; Genomic_DNA.
DR   RefSeq; YP_001102288.1; NC_009142.1.
DR   ProteinModelPortal; A4F5N8; -.
DR   STRING; A4F5N8; -.
DR   GeneID; 4939870; -.
DR   GenomeReviews; AM420293_GR; SACE_0009.
DR   KEGG; sen:SACE_0009; -.
DR   eggNOG; COG0188; -.
DR   OMA; TGRGRIY; -.
DR   PhylomeDB; A4F5N8; -.
DR   ProtClustDB; PRK05560; -.
DR   BioCyc; SERY405948:SACE_0009-MONOMER; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; SACEN_1.PE7; -.
DR   PRODOM; SACEN_1_PE7.
DR   SWISS-2DPAGE; SACEN_1_PE7.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   831 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTETLPPEHG RIEPVDIQQE MQNSYINYAM SVIVARALPD VRDGLKPVHR RVLYSMYDSG
     YRPDRGYVKC SRVVGDVMGN YHPHGDSSIY DTLVRLAQPW SMRHPLIDGQ GNFGSPGNDP
     AAAMRYTESR LDPLAMHMLA DIEEDTVDFS DNYDGRSQEP DVLPARIPNL LVNGGGGIAV
     GMATNIPPHN LREVADGVVW ALENPEADDE ALLEALIERI KGPDFPTRGL IMGTNAIADA
     YRTGRGSIKM RAVVDVEEDT KGRTSLVVTE LPYQVNPDNL IESIAAMHRE GKLTGISDIA
     DESNSRRGMR IVITLKRDSI PKVVLNNLYK HTQLQYTFGV NMLALVEGVP RTLRLDQVIR
     HYVKHQVEVI VRRTRFRLRK AEERAHILRG LVKALDMLDE VIALIRRSPT VDDARTGLIE
     LLEVDEVQAN AILEMQLRRL AALERQKIVD QLAEIEREIE DLKDILDKPE RQRQIIRDEL
     MAIVDKHGDD RRTRIVPHEG EVSMEDLIAD EDVVVTLTRT GYAKRTRTDL YRAQKRGGKG
     VQGAQLKQDD IVSHFFVCST HDWILFFTNK GRVYRAKAYE LPEANRTARG QHVANLLAFQ
     PDEHIAQVMQ IKDYTAAPYL VLATRNGLVK KSRLTDFDSN RSGGLIGVNL KDDDELVGAV
     LCSADDDLLL VSAEGQSIRF HASDEALRPM GRATSGVLGM RFNEGDELLA MGVVRPDRYV
     LVATDGGYAK RTPIDDYPVQ GRGGKGVLTI QYDRKRGRLV GALIVDVDDE LYAITSTGGV
     IRTTAKEVRK AGRQTKGVRL MNLGDGTSVV AVARNADEAA DPDAAGPEQQ K
//

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