(data stored in ACNUC7421 zone)

HOGENOM: SALPK_1_PE1013

ID   SALPK_1_PE1013                       STANDARD;      PRT;   282 AA.
AC   SALPK_1_PE1013; B5BI72;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
DE   Short=CMK; EC=2.7.1 148;AltName:
DE   Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase;
DE   (SALPK_1.PE1013).
GN   Name=ispE; OrderedLocusNames=SSPA1021;
OS   SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR PARATYPHI A STR. AKU_12601.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=554290;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SALPK_1.PE1013.
CC       Salmonella enterica subsp. enterica serovar Paratyphi A str. AKU_12601
CC       chromosome, complete genome.
CC   -!- ANNOTATIONS ORIGIN:ISPE_SALPK
CC   -!- FUNCTION: Catalyzes the phosphorylation of the position 2 hydroxy
CC       group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-
CC       erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-
CC       D-erythritol.
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate
CC       biosynthesis via DXP pathway; isopentenyl diphosphate from 1-
CC       deoxy-D-xylulose 5-phosphate: step 3/6.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. IspE subfamily.
CC   -!- GENE_FAMILY: HOG000019601 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B5BI72; -.
DR   EMBL; FM200053; CAR59174.1; -; Genomic_DNA.
DR   RefSeq; YP_002141862.1; NC_011147.1.
DR   ProteinModelPortal; B5BI72; -.
DR   SMR; B5BI72; 2-282.
DR   STRING; B5BI72; -.
DR   GeneID; 6810308; -.
DR   GenomeReviews; FM200053_GR; SSPA1021.
DR   KEGG; sek:SSPA1021; -.
DR   OMA; LNLFLHV; -.
DR   ProtClustDB; PRK00343; -.
DR   GO; GO:0050515; F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00061; IspE; 1; -.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR004424; IspE.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   PANTHER; PTHR20861:SF2; IspE; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF010376; IspE; 1.
DR   SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1.
DR   TIGRFAMs; TIGR00154; IspE; 1.
DR   HOGENOMDNA; SALPK_1.PE1013; -.
KW   ATP-binding; Complete proteome; Isoprene biosynthesis; Kinase;
KW   Nucleotide-binding; Transferase.
SQ   SEQUENCE   282 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTHWPSPAKL NLFLYITGQR ADGYHTLQTL FQFLDYGDTL HIEPRRDGEI HLLTPVNGVE
     NEDNLIVRAA QLLMKIASES GRLPAGSGAD ISIEKRLPMG GGLGGGSSNA ATVLVALNHL
     WQCGLSIDEL ATLGLTLGAD VPVFVRGHAA FAEGVGEILT PVNPPEKWYL VAHPGVSIPT
     PVIFKDPQLP RNTPKRSIDT LLKCEFSNDC EVIARKRFRE VDAALSWLLE YAPSRLTGTG
     ACVFAEFDTE SCARQVLEQA PEWLNAFVAK GVNLSPLHRE LL
//

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