(data stored in ACNUC5835 zone)

HOVERGEN: SCF_BOVIN

ID   SCF_BOVIN               Reviewed;         274 AA.
AC   Q28132; Q9TU74;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   13-OCT-2009, entry version 69.
DE   RecName: Full=Kit ligand;
DE   AltName: Full=C-kit ligand;
DE   AltName: Full=Stem cell factor;
DE            Short=SCF;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MGF;
DE   Flags: Precursor;
GN   Name=KITLG; Synonyms=SCF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Spleen;
RX   MEDLINE=94339176; PubMed=7520283; DOI=10.1016/0167-4889(94)90084-1;
RA   Zhou J., Hikono H., Ohtaki M., Kubota T., Sakurai M.;
RT   "Cloning and characterization of cDNAs encoding two normal isoforms of
RT   bovine stem cell factor.";
RL   Biochim. Biophys. Acta 1223:148-150(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC   TISSUE=Fetal brain;
RA   Kudo T.;
RT   "Bovine counterpart of stem cell factor.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-239, AND VARIANT ASP-218.
RC   STRAIN=Belgian blue;
RX   MEDLINE=99315331; PubMed=10384045; DOI=10.1007/s003359901076;
RA   Seitz J.J., Schmutz S.M., Thue T.D., Buchanan F.C.;
RT   "A missense mutation in the bovine MGF gene is associated with the
RT   roan phenotype in Belgian Blue and Shorthorn cattle.";
RL   Mamm. Genome 10:710-712(1999).
CC   -!- FUNCTION: Stimulates the proliferation of mast cells. Able to
CC       augment the proliferation of both myeloid and lymphoid
CC       hematopoietic progenitors in bone marrow culture. Mediates also
CC       cell-cell adhesion. Acts synergistically with other cytokines,
CC       probably interleukins (By similarity).
CC   -!- SUBUNIT: Homodimer, non-covalently linked (Probable).
CC   -!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I
CC       membrane protein (By similarity). Secreted (By similarity).
CC       Note=Also exists as a secreted soluble form (isoform 1 only) (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I
CC       membrane protein (By similarity). Cytoplasm, cytoskeleton (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q28132-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q28132-2; Sequence=VSP_006020;
CC   -!- PTM: A soluble form is produced by proteolytic processing of
CC       isoform 1 in the extracellular domain (By similarity).
CC   -!- POLYMORPHISM: The roan locus is responsible for the coat
CC       coloration of Belgian Blue and Shorthorn cattle. The solid-colored
CC       and white animals are homozygotes, and the roan animals, with
CC       intermingled colored and white hairs, are heterozygous. The roan
CC       phenotype is due to the Asp-218 mutation.
CC   -!- SIMILARITY: Belongs to the SCF family.
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CC   -!- GENE_FAMILY: HBG036146 [ FAMILY / ALN / TREE ]
DR   EMBL; D28934; BAA06061.1; -; mRNA.
DR   EMBL; AB033716; BAA94808.1; -; mRNA.
DR   EMBL; AF120154; AAD55355.1; -; Genomic_DNA.
DR   IPI; IPI00691569; -.
DR   IPI; IPI00693469; -.
DR   PIR; S47571; S47571.
DR   RefSeq; NP_776800.1; -.
DR   UniGene; Bt.354; -.
DR   SMR; Q28132; 29-161.
DR   STRING; Q28132; -.
DR   Ensembl; ENSBTAT00000023349; ENSBTAP00000023349; ENSBTAG00000017549; Bos taurus.
DR   GeneID; 281885; -.
DR   KEGG; bta:281885; -.
DR   CTD; 281885; -.
DR   HOVERGEN; Q28132; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR003452; SCF.
DR   PANTHER; PTHR11574; SCF; 1.
DR   Pfam; PF02404; SCF; 1.
DR   PIRSF; PIRSF015599; SCF; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q28132.
DR   SWISS-2DPAGE; Q28132.
KW   Alternative splicing; Cell adhesion; Cell membrane; Cytoplasm;
KW   Cytoskeleton; Disulfide bond; Glycoprotein; Growth factor; Membrane;
KW   Polymorphism; Secreted; Signal; Transmembrane.
FT   DOMAIN        1    119       PRODOM:2005.1:PD005657  20
FT   DOMAIN      122    209       PRODOM:2005.1:PD006155  15
FT   DOMAIN      211    274       PRODOM:2005.1:PD981191  13
FT   SIGNAL        1     25       Potential.
FT   CHAIN        26    274       Kit ligand.
FT                                /FTId=PRO_0000031908.
FT   TOPO_DOM     26    215       Extracellular (Potential).
FT   TRANSMEM    216    238       Potential.
FT   TOPO_DOM    239    274       Cytoplasmic (Potential).
FT   CARBOHYD     90     90       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    145    145       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    196    196       N-linked (GlcNAc...) (Potential).
FT   DISULFID     29    114       By similarity.
FT   DISULFID     68    164       By similarity.
FT   VAR_SEQ     175    203       DSRVSVTKPFMLPPVAASSLRNDSSSSNR -> G (in
FT                                isoform 2).
FT                                /FTId=VSP_006020.
FT   VARIANT     218    218       A -> D (in allele roan).
SQ   SEQUENCE   274 AA;  31015 MW;  D6C1DDB77B0CB12B CRC64;
     MKKTQTWIIT CIYLQLLLFN PLVHTQGICS NRVTDDVKDV TKLVANLPKD YMITLKYVPG
     MDVLPSHCWI SEMVEQLSVS LTDLLDKFSN ISEGLSNYCI IDKLVKIVDD LVECMEEHSS
     ENVKKSSKSP EPRQFTPEKF FGIFNKSIDA FKDLEIVASK MSECVISSTS SPEKDSRVSV
     TKPFMLPPVA ASSLRNDSSS SNRKASNSIE DSSLQWAAVA LPAFFSLVIG FAFGAFYWKK
     KQPNLTRTVE NRQINEEDNE ISMLQEKERE FQEV
//

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