(data stored in ACNUC5835 zone)

HOVERGEN: SCF_CHICK

ID   SCF_CHICK               Reviewed;         287 AA.
AC   Q09108;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-NOV-2009, entry version 61.
DE   RecName: Full=Kit ligand;
DE   AltName: Full=C-kit ligand;
DE   AltName: Full=Stem cell factor;
DE            Short=SCF;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MGF;
DE   Contains:
DE     RecName: Full=Processed kit ligand;
DE   Flags: Precursor;
GN   Name=KITLG; Synonyms=SCF;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=93273244; PubMed=7684722; DOI=10.1016/0378-1119(93)90732-I;
RA   Zhou J., Ohtaki M., Sakurai M.;
RT   "Sequence of a cDNA encoding chicken stem cell factor.";
RL   Gene 127:269-270(1993).
CC   -!- FUNCTION: Stimulates the proliferation of mast cells. Able to
CC       augment the proliferation of both myeloid and lymphoid
CC       hematopoietic progenitors in bone marrow culture. Mediates also
CC       cell-cell adhesion. Acts synergistically with other cytokines,
CC       probably interleukins (By similarity).
CC   -!- SUBUNIT: Homodimer, non-covalently linked (Probable).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- SUBCELLULAR LOCATION: Processed kit ligand: Secreted (By
CC       similarity).
CC   -!- DEVELOPMENTAL STAGE: Acts in the early stages of hematopoiesis.
CC   -!- PTM: A soluble form is produced by proteolytic processing of the
CC       extracellular domain (By similarity).
CC   -!- SIMILARITY: Belongs to the SCF family.
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CC   -!- GENE_FAMILY: HBG036146 [ FAMILY / ALN / TREE ]
DR   EMBL; D13516; BAA02733.1; -; mRNA.
DR   IPI; IPI00591688; -.
DR   PIR; JN0637; JN0637.
DR   RefSeq; NP_990461.1; -.
DR   UniGene; Gga.605; -.
DR   STRING; Q09108; -.
DR   Ensembl; ENSGALT00000018268; ENSGALP00000018246; ENSGALG00000011206; Gallus gallus.
DR   GeneID; 396028; -.
DR   CTD; 396028; -.
DR   HOGENOM; Q09108; -.
DR   HOVERGEN; Q09108; -.
DR   OMA; LPSHCWI; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR003452; SCF.
DR   PANTHER; PTHR11574; SCF; 1.
DR   Pfam; PF02404; SCF; 1.
DR   PIRSF; PIRSF015599; SCF; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q09108.
DR   SWISS-2DPAGE; Q09108.
KW   Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein;
KW   Growth factor; Membrane; Secreted; Signal; Transmembrane.
FT   DOMAIN        1    118       PRODOM:2005.1:PD005657  20
FT   DOMAIN      127    206       PRODOM:2005.1:PD006155  15
FT   DOMAIN      222    287       PRODOM:2005.1:PD981191  13
FT   SIGNAL        1     25       Potential.
FT   CHAIN        26    287       Kit ligand.
FT                                /FTId=PRO_0000031919.
FT   CHAIN        26      ?       Processed kit ligand.
FT                                /FTId=PRO_0000292279.
FT   TOPO_DOM     26    225       Extracellular (Potential).
FT   TRANSMEM    226    246       Potential.
FT   TOPO_DOM    247    287       Cytoplasmic (Potential).
FT   CARBOHYD    100    100       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    149    149       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    200    200       N-linked (GlcNAc...) (Potential).
FT   DISULFID     29    117       By similarity.
FT   DISULFID     68    167       By similarity.
SQ   SEQUENCE   287 AA;  32328 MW;  6AE8556ADC152578 CRC64;
     MKKAQTWIIT CFCLQLLLLN PLVKAQSSCG NPVTDDVNDI AKLVGNLPND YLITLKYVPK
     MDSLPNHCWL HLMVPEFSRS LHNLLQKFSD ISDMSDVLSN YSIINNLTRI INDLMACLAF
     DKNKDFIKEN GHLYEEDRFI PENFFRLFNS TIEVYKEFAD SLDKNDCIMP STVETPENDS
     RVAVTKTISF PPVAASSLRN DSIGSNTSSN SNKEALGFIS SSSLQGISIA LTSLLSLLIG
     FILGAIYWKK THPKSRPESN ETIQCHGCQE ENEISMLQQK EKEHLQV
//

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