(data stored in ACNUC5835 zone)

HOVERGEN: SCF_FELCA

ID   SCF_FELCA               Reviewed;         274 AA.
AC   P79169;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   13-OCT-2009, entry version 60.
DE   RecName: Full=Kit ligand;
DE   AltName: Full=C-kit ligand;
DE   AltName: Full=Stem cell factor;
DE            Short=SCF;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MGF;
DE   Flags: Precursor;
GN   Name=KITLG; Synonyms=SCF;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX   MEDLINE=97069946; PubMed=8912926;
RA   Dunham S.P., Onions D.E.;
RT   "The cloning and sequencing of cDNAs encoding two isoforms of feline
RT   stem cell factor.";
RL   DNA Seq. 6:233-237(1996).
CC   -!- FUNCTION: Stimulates the proliferation of mast cells. Able to
CC       augment the proliferation of both myeloid and lymphoid
CC       hematopoietic progenitors in bone marrow culture. Mediates also
CC       cell-cell adhesion. Acts synergistically with other cytokines,
CC       probably interleukins (By similarity).
CC   -!- SUBUNIT: Homodimer, non-covalently linked (Probable).
CC   -!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I
CC       membrane protein (By similarity). Secreted (By similarity).
CC       Note=Also exists as a secreted soluble form (isoform 1 only) (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I
CC       membrane protein (By similarity). Cytoplasm, cytoskeleton (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P79169-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P79169-2; Sequence=VSP_006021;
CC   -!- PTM: A soluble form is produced by proteolytic processing of
CC       isoform 1 in the extracellular domain (By similarity).
CC   -!- SIMILARITY: Belongs to the SCF family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
CC   -!- GENE_FAMILY: HBG036146 [ FAMILY / ALN / TREE ]
DR   EMBL; D50833; BAA09445.1; -; mRNA.
DR   RefSeq; NP_001009343.1; -.
DR   SMR; P79169; 29-161.
DR   GeneID; 493937; -.
DR   CTD; 493937; -.
DR   HOVERGEN; P79169; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005173; F:stem cell factor receptor binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR003452; SCF.
DR   PANTHER; PTHR11574; SCF; 1.
DR   Pfam; PF02404; SCF; 1.
DR   PIRSF; PIRSF015599; SCF; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P79169.
DR   SWISS-2DPAGE; P79169.
KW   Alternative splicing; Cell adhesion; Cell membrane; Cytoplasm;
KW   Cytoskeleton; Disulfide bond; Glycoprotein; Growth factor; Membrane;
KW   Secreted; Signal; Transmembrane.
FT   DOMAIN        1    116       PRODOM:2005.1:PD005657  20
FT   DOMAIN      122    205       PRODOM:2005.1:PD006155  15
FT   DOMAIN      211    274       PRODOM:2005.1:PD981191  13
FT   SIGNAL        1     25       Potential.
FT   CHAIN        26    274       Kit ligand.
FT                                /FTId=PRO_0000031911.
FT   TOPO_DOM     26    215       Extracellular (Potential).
FT   TRANSMEM    216    238       Potential.
FT   TOPO_DOM    239    274       Cytoplasmic (Potential).
FT   CARBOHYD     90     90       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     97     97       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    145    145       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    196    196       N-linked (GlcNAc...) (Potential).
FT   DISULFID     29    114       By similarity.
FT   DISULFID     68    164       By similarity.
FT   VAR_SEQ     175    203       DSRVSVTKPFMLPPVAASSLRNDSSSSNR -> G (in
FT                                isoform 2).
FT                                /FTId=VSP_006021.
SQ   SEQUENCE   274 AA;  30988 MW;  C5B78DB4791237BE CRC64;
     MKKTQTWIVT CIYLQLLLFN PLVKTKGLCR NRVTDDVKDV TKLVANLPKD YKIALKYVPG
     MDVLPSHCWI SVMVEQLSVS LTDLLDKFSN ISEGLSNYSI IDKLVKIVDD LVECVEGHSS
     ENVKKSSKSP EPRLFTPEEF FRIFNRSIDA FKDLEMVASK TSECVVSSTL SPEKDSRVSV
     TKPFMLPPVA ASSLRNDSSS SNRKATNPIE DSSIQWAVMA LPACFSLVIG FAFGAFYWKK
     KQPNLTRTVE NIQINEEDNE ISMLQEKERE FQEV
//

If you have problems or comments...

PBIL Back to PBIL home page