(data stored in ACNUC14238 zone)

HOGENOM: SCHPO_1_PE1

ID   SCHPO_1_PE1                          STANDARD;      PRT;   1887 AA.
AC   SCHPO_1_PE1; Q5EAK4; Q9HGP6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=ATP-dependent DNA helicase tlh1; EC=3.6.4 12;AltName:
DE   Full=Sub-telomeric helicase RecQ homolog 1; (SCHPO_1.PE1).
GN   Name=tlh1; ORFNames=SPAC212.11;
OS   SCHIZOSACCHAROMYCES POMBE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SCHPO_1.PE1.
CC       Schizosaccharomyces pombe chromosome I EF1 full sequence 1..5579133
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:TLH1_SCHPO
CC   -!- FUNCTION: Exhibits ATP-dependent 3' to 5' DNA helicase activity
CC       and has a role in telomerase-independent telomere maintenance.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC   -!- SIMILARITY: Contains 1 CCHC-type zinc finger.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- GENE_FAMILY: HOG000213224 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Schizosaccharomyces_pombe;SPAC212.11;SPAC212.11-1;SPAC212.11-1.
DR   UniProtKB/Swiss-Prot; Q5EAK4; Q9HGP6; -.
DR   EMBL; BK005597; DAA05660.1; -; mRNA.
DR   EMBL; CU329670; CAC05745.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q5EAK4; -.
DR   TCDB; 2.A.16.2.2; telurite-resistance/dicarboxylate transporter (TDT) family.
DR   EnsemblFungi; SPAC212.11-1; SPAC212.11-1; SPAC212.11.
DR   GenomeReviews; CU329670_GR; tlh1.
DR   GeneDB_Spombe; SPAC212.11; -.
DR   GeneTree; EFGT00050000000108; -.
DR   OrthoDB; EOG4XH37R; -.
DR   GO; GO:0000781; C:chromosome, telomeric region; IDA:GeneDB_Spombe.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; NAS:GeneDB_Spombe.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; TAS:GeneDB_Spombe.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEP:GeneDB_Spombe.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR004695; C4_dicarb_/mal_transpt.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR   InterPro; IPR022698; DUF3505.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR001878; Znf_CCHC.
DR   PANTHER; PTHR13710; RecQ; 1.
DR   Pfam; PF03595; C4dic_mal_tran; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF12013; DUF3505; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00343; ZnF_C2HC; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
DR   HOGENOMDNA; SCHPO_1.PE1; -.
KW   SPAC212.1100037236820036002503210000011;
KW   Q5EAK4;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; Metal-binding;
KW   Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.
SQ   SEQUENCE   1887 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVVASEIAKV ASKTARDIAG CFTCQCGTQF DNVERIVQHF KECRYRDETC KDDDIVVYEP
     SSFVQDEKKD KPIIVEAASE ATSEEACNSS KERQLPALSA LSALSTLTTS ANDDLWTARL
     IWQSTNDTKL DNSPSSNYTD LNHKLANYGL SILSIHALMC VECECLLNVI HTAQHMQIVH
     KLELNEDLLW FQELRTLKLK SPTNVLQTHS SQTHVYPYIR GLPVLLNGYE CVPCTKNGTG
     FVHAIMDTFR HHVRRTHGKV IKLENCIRRT ALQTVKNKYA QRCQFFKVDY VPLNGGEEEE
     EEEGEEKEDA QNIKERMVDF CFSKFMEKNQ QRREQQDKGE NKKRQDDVDQ ATDNNTNTIL
     EDDEKDNDEE EEEEIVNARE KNLLNQQFNW TAIVKKLGEN WDQLVRFEYT NGIVTLDTIV
     NQLIRYYYRG FRHLSGMTMG MRRMFTQGGS YSAQERGLCR LEQKDTVVRY AQSAALYLIF
     LLRRPSADSG IRRHLEAMCG ATVERKEGGS NSSSNISNVA NFDSAEDDND NDNDNDRDSN
     NNNNNNNTNT DDDDKLAYLE LHEALKLAFL QQYDFSKNVQ DLEIMEFLAC MSLHKDGTSK
     YAYEISACFA PLIYTCRLVA ACELQRLIDE KQIDLLSIPS FQTAGSIAYA HVFCFITLGQ
     RNLYDVLYET QKVVRDIIRT EGYANTLQGL SPSTVLFQPR SNSMYPCIGD AFNNMVRLDL
     SELTALYEGM FAKVQDLLKE LCFDMNVEKL LPISLLRSIG DDINNSKLGY SFFKESIEIR
     SSHSVLLRTI LKNSELCHRF FPSMSKKDLT KLFGGVSDQQ RNECDNYSNH YNDNSNDNDN
     DVFLKLHWSK SAIKKYETKA SIFNELLFCL VYISAGQPAR AQEMVYWTLR NGKYKTRELY
     LMFGRLMIYS RYDKTRNMKF AEKPIPRFLS EPLSILALRY YVLVRPLEAL MKYVTTADRS
     KVAVYLDFMF VIAGERLQRD LPYRIFPKAT YQCIQKPLGF RNYRHIAHYF KEKNIEEEMT
     RESYFDLQAG HTRNTALYIY GRTMDNLHYL PSDYFANFFR ASYKWQELLQ IRDNPTHGLL
     VETKHPFIKR VDQLEEALNE KLARLVGEQM VEGDKEKDKT NEEKNKDEVK AEMTQPVVNQ
     DSHDLQDQLA TTPTAPTAFH YRPGLLQPSQ TSVQHCCWAL SQYYGLEAKF RSLKQFQSVY
     FSLLNRMNLI TVLPTGGGKS LSFLIPALIE KKRQTPGKVM NMVTLVLVPM MSLRQDMMLR
     VNEKGLLVCS GNWTAFKDVR LTLETQLPDL FILTYESALT NSGLRFFESL ATLGRLARVV
     IDEAHLLLTS GAWRTALSRA SRLSGLYAPL HLLSATFPRQ LEMVARQTFC TNFYVLRETS
     TARENIFYFL HPYDNTEFLL DLRTLMKRTK VFEGDGRAII FCRTKKDVEY IHRRLHQSDL
     FAHTHVTIYT GDVSDEERQM NFDAFRNANG KTRIMIATKA FGLGINYMGV RLVVHYGLPA
     SSMDYVQETG RAGRDGKYAI AALFYEKYDS TWSSYVEDSM KNFLNDNTMC VRSFLASEMD
     GECVCCASFA NCVYCSRCSD SLLGEESTVS TMYGVKPTLP ETPKPAIATH SRYNASFSSS
     PPPQPGNSSG MSAMNTNTTS TTPVSLSELS EITLFPSSVS PTWKKSFGNA NTNLKYGLED
     MSLSHRRGHK RTYDEHLNNV QQGVNHDMNR VHGSVGGMSG IVGIGIGIGD GDGDGDVDSR
     TIHFAEYKSR VQAVKKQWVD STDISAQLER FFRVYKDECL SCTLGNPDTE IRAHTGKACP
     VRLSTCYKCG KADHNLRECK LRIRFQGLCL FCGLTKFEHA DSDMAYTSDC RSWARKANLI
     SLVYYAWNNV QYRRTIADKF LQGDVRD
//

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