(data stored in ACNUC8465 zone)

HOGENOM: SCHPO_1_PE260

ID   SCHPO_1_PE260                        STANDARD;      PRT;   340 AA.
AC   SCHPO_1_PE260; P10506;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein kinase byr1; EC=2.7.12 2;AltName: Full=MAPK kinase;
DE   Short=MAPKK; (SCHPO_1.PE260).
GN   Name=byr1; Synonyms=ste1; ORFNames=SPAC1D4.13;
OS   SCHIZOSACCHAROMYCES POMBE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SCHPO_1.PE260.
CC       Schizosaccharomyces pombe chromosome I EF1 full sequence 1..5579133
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:BYR1_SCHPO
CC   -!- FUNCTION: Serine/threonine protein kinase involved in conjugation
CC       and sporulation. It is thought that it is phosphorylated by the
CC       byr2 protein kinase and that it can phosphorylate the spk1 kinase.
CC       When bound to bob1, is involved in the regulation of sexual
CC       differentiation.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with bob1 and spk1.
CC   -!- INTERACTION:
CC       O94307:bob1; NbExp=2; IntAct=EBI-2042633, EBI-2042611;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Localizes to the cell tips
CC       and septum forming regions.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Schizosaccharomyces_pombe;SPAC1D4.13;SPAC1D4.13-1;SPAC1D4.13-1.
DR   UniProtKB/Swiss-Prot; P10506; -.
DR   EMBL; X07445; CAA30326.1; -; Genomic_DNA.
DR   EMBL; CU329670; CAA93222.1; -; Genomic_DNA.
DR   PIR; S00473; OKBYR1.
DR   RefSeq; NP_593026.1; NM_001018425.1.
DR   ProteinModelPortal; P10506; -.
DR   IntAct; P10506; 2.
DR   STRING; P10506; -.
DR   EnsemblFungi; SPAC1D4.13-1; SPAC1D4.13-1; SPAC1D4.13.
DR   GeneID; 2542137; -.
DR   GenomeReviews; CU329670_GR; byr1.
DR   KEGG; spo:SPAC1D4.13; -.
DR   NMPDR; fig|4896.1.peg.2996; -.
DR   GeneDB_Spombe; SPAC1D4.13; -.
DR   eggNOG; fuNOG07450; -.
DR   GeneTree; EFGT00050000000597; -.
DR   OMA; KVIQLNI; -.
DR   OrthoDB; EOG43V342; -.
DR   PhylomeDB; P10506; -.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-000747-MON; -.
DR   BRENDA; 2.7.12.2; 5615.
DR   ArrayExpress; P10506; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_Spombe.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_Spombe.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; TAS:GeneDB_Spombe.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000751; P:cell cycle arrest in response to pheromone; TAS:GeneDB_Spombe.
DR   GO; GO:0006995; P:cellular response to nitrogen starvation; IGI:GeneDB_Spombe.
DR   GO; GO:0000165; P:MAPKKK cascade; NAS:GeneDB_Spombe.
DR   GO; GO:0032005; P:regulation of conjugation with cellular fusion by signal transduction; IGI:GeneDB_Spombe.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; SCHPO_1.PE260; -.
KW   SPAC1D4.13c6c37236820036002503210000011;
KW   P10506;
KW   ATP-binding; Complete proteome; Conjugation; Cytoplasm; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Sporulation; Transferase.
SQ   SEQUENCE   340 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFKRRRNPKG LVLNPNASVK SSDNDHKEEL INNQKSFESN VEAFMEQCAH MNRRPAWISD
     LDNSSLEVVR HLGEGNGGAV SLVKHRNIFM ARKTVYVGSD SKLQKQILRE LGVLHHCRSP
     YIVGFYGAFQ YKNNISLCME YMDCGSLDAI LREGGPIPLD ILGKIINSMV KGLIYLYNVL
     HIIHRDLKPS NVVVNSRGEI KLCDFGVSGE LVNSVAQTFV GTSTYMSPER IRGGKYTVKS
     DIWSLGISII ELATQELPWS FSNIDDSIGI LDLLHCIVQE EPPRLPSSFP EDLRLFVDAC
     LHKDPTLRAS PQQLCAMPYF QQALMINVDL ASWASNFRSS
//

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