(data stored in ACNUC14511 zone)

HOGENOM: SCHPO_1_PE541

ID   SCHPO_1_PE541                        STANDARD;      PRT;   347 AA.
AC   SCHPO_1_PE541; O14230; P78756;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Farnesyl pyrophosphate synthase; Short=FPP synthase;
DE   Short=FPS; EC=2.5.1.10;AltName: Full=(2E,6E)-farnesyl diphosphate
DE   synthase;AltName: Full=Dimethylallyltranstransferase; EC=2.5.1 1;AltName:
DE   Full=Farnesyl diphosphate synthase;AltName: Full=Geranyltranstransferase;
DE   (SCHPO_1.PE541).
GN   Name=fps1; ORFNames=SPAC6F12.13c;
OS   SCHIZOSACCHAROMYCES POMBE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SCHPO_1.PE541.
CC       Schizosaccharomyces pombe chromosome I EF1 full sequence 1..5579133
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:FPPS_SCHPO
CC   -!- FUNCTION: Catalyzes the sequential condensation of isopentenyl
CC       pyrophosphate with the allylic pyrophosphates, dimethylallyl
CC       pyrophosphate, and then with the resultant geranylpyrophosphate to
CC       the ultimate product farnesyl pyrophosphate.
CC   -!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
CC       diphosphate = diphosphate + geranyl diphosphate.
CC   -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
CC       = diphosphate + (2E,6E)-farnesyl diphosphate.
CC   -!- COFACTOR: Binds 3 magnesium ions per subunit (By similarity).
CC   -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate
CC       biosynthesis; farnesyl diphosphate from geranyl diphosphate and
CC       isopentenyl diphosphate: step 1/1.
CC   -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate
CC       biosynthesis; geranyl diphosphate from dimethylallyl diphosphate
CC       and isopentenyl diphosphate: step 1/1.
CC   -!- SUBUNIT: Interacts with spo9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC   -!- GENE_FAMILY: HOG000160912 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Schizosaccharomyces_pombe;SPAC6F12.13C;SPAC6F12.13C-1;SPAC6F12.13C-1.
DR   UniProtKB/Swiss-Prot; O14230; P78756; -.
DR   EMBL; CU329670; CAB11097.1; -; Genomic_DNA.
DR   EMBL; D89104; BAA13767.1; -; mRNA.
DR   PIR; T11664; T11664.
DR   PIR; T42081; T42081.
DR   RefSeq; NP_593299.1; NM_001018729.1.
DR   ProteinModelPortal; O14230; -.
DR   STRING; O14230; -.
DR   EnsemblFungi; SPAC6F12.13c-1; SPAC6F12.13c-1; SPAC6F12.13c.
DR   GeneID; 2542898; -.
DR   GenomeReviews; CU329670_GR; fps1.
DR   KEGG; spo:SPAC6F12.13c; -.
DR   NMPDR; fig|4896.1.peg.3269; -.
DR   GeneDB_Spombe; SPAC6F12.13c; -.
DR   eggNOG; fuNOG05213; -.
DR   GeneTree; EFGT00050000002300; -.
DR   OMA; RDFMAVF; -.
DR   OrthoDB; EOG4SFDFW; -.
DR   PhylomeDB; O14230; -.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-000998-MON; -.
DR   ArrayExpress; O14230; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_Spombe.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_Spombe.
DR   GO; GO:0004161; F:dimethylallyltranstransferase activity; IGI:GeneDB_Spombe.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:GeneDB_Spombe.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006696; P:ergosterol biosynthetic process; IGI:GeneDB_Spombe.
DR   GO; GO:0045337; P:farnesyl diphosphate biosynthetic process; IGI:GeneDB_Spombe.
DR   GO; GO:0070317; P:negative regulation of G0 to G1 transition; IMP:GeneDB_Spombe.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   SUPFAM; SSF48576; Terpenoid_synth; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
DR   HOGENOMDNA; SCHPO_1.PE541; -.
KW   SPAC6F12.13c4c7236820036002503210000011;
KW   O14230;
KW   Cholesterol biosynthesis; Complete proteome; Cytoplasm;
KW   Isoprene biosynthesis; Lipid synthesis; Magnesium; Metal-binding;
KW   Nucleus; Reference proteome; Steroid biosynthesis;
KW   Sterol biosynthesis; Transferase.
SQ   SEQUENCE   347 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSAVDKRAKF ESALPVFVDE IVNYLKTINI PDDVTEWYKN SLFHNTLGGK YNRGLSVIDS
     YEILLGHPLD EAAYMKAAVL GWMVELLQSF FLIADDIMDA SKTRRGQPCW YLMPGVGNIA
     INDAFMVESA IYFLLKKHFR QESCYVDLIE LFHDVTFQTE LGQQLDLLTA PEDSVDLSKF
     SLQKHSFIVI YKTAFYSFYL PVALAMHLAG VATPENLKCA QDILIILGKY FQVQDDYLDC
     YGDPTVTGKI GTDILDNKCS WIINLALAKC TPEQRVILDD NYGRKDSESE KRVKAVFEEL
     NIRGEFENYE ESEVSEIKKL IDGVDESTGL KKSIFTTFLG KIYKRNK
//

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