(data stored in ACNUC8465 zone)

HOGENOM: SCHPO_2_PE1748

ID   SCHPO_2_PE1748                       STANDARD;      PRT;   363 AA.
AC   SCHPO_2_PE1748; Q9Y884; Q9UUK6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=MAP kinase kinase skh1/pek1; EC=2.7.12 2; (SCHPO_2.PE1748).
GN   Name=skh1; Synonyms=mkk1, pek1; ORFNames=SPBC543.07;
OS   SCHIZOSACCHAROMYCES POMBE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SCHPO_2.PE1748.
CC       Schizosaccharomyces pombe chromosome II EF1 full sequence 1..4539804
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:SKH1_SCHPO
CC   -!- FUNCTION: Involved in the mkh1 signal transduction pathway that
CC       plays a role in cell wall integrity. Activates spm1/pmk1 via
CC       phosphorylation.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated by mkh1.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Schizosaccharomyces_pombe;SPBC543.07;SPBC543.07-1;SPBC543.07-1.
DR   UniProtKB/Swiss-Prot; Q9Y884; Q9UUK6; -.
DR   EMBL; AF157632; AAD41399.1; -; Genomic_DNA.
DR   EMBL; D82023; BAA82312.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAC05249.1; -; Genomic_DNA.
DR   PIR; T51294; T51294.
DR   PIR; T51992; T51992.
DR   RefSeq; NP_596795.1; NM_001023815.1.
DR   ProteinModelPortal; Q9Y884; -.
DR   STRING; Q9Y884; -.
DR   EnsemblFungi; SPBC543.07-1; SPBC543.07-1; SPBC543.07.
DR   GeneID; 2540919; -.
DR   GenomeReviews; CU329671_GR; skh1.
DR   KEGG; spo:SPBC543.07; -.
DR   NMPDR; fig|4896.1.peg.2661; -.
DR   GeneDB_Spombe; SPBC543.07; -.
DR   eggNOG; fuNOG04753; -.
DR   GeneTree; EFGT00050000000597; -.
DR   OMA; INADPNP; -.
DR   OrthoDB; EOG4D29ZP; -.
DR   PhylomeDB; Q9Y884; -.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-004776-MON; -.
DR   BRENDA; 2.7.12.2; 5615.
DR   ArrayExpress; Q9Y884; -.
DR   GO; GO:0030428; C:cell septum; IDA:GeneDB_Spombe.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_Spombe.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_Spombe.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; TAS:GeneDB_Spombe.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0051519; P:activation of bipolar cell growth; IMP:GeneDB_Spombe.
DR   GO; GO:0033205; P:cell cycle cytokinesis; NAS:GeneDB_Spombe.
DR   GO; GO:0006883; P:cellular sodium ion homeostasis; NAS:GeneDB_Spombe.
DR   GO; GO:0031505; P:fungal-type cell wall organization; NAS:GeneDB_Spombe.
DR   GO; GO:0000165; P:MAPKKK cascade; IDA:GeneDB_Spombe.
DR   GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IMP:GeneDB_Spombe.
DR   GO; GO:0008360; P:regulation of cell shape; NAS:GeneDB_Spombe.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; SCHPO_2.PE1748; -.
KW   SPBC543.07cccc7236820036002503210000011;
KW   Q9Y884;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   363 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSKKPVLNLD TSNGFSEEYI SHPERNDNQG IVEITDLVFS SESKLTQRKE SRDSKTFVPS
     FLEELDDDHL HELVTNGGIL YMNSLGEGVS GSVRKCRIRG TQMIFAMKTV LAAPNTALQK
     QLLRELKINR SCTSPYIVKY YGACYNNAEC QLNIAMEYCG AGSLDAIYKR VRSQGGRTGE
     RPLGKIAFGV LSGLSYLHDR KIIHRDIKPS NILLTSKGQV KLCDFGVSGE LVNSLAGTFT
     GTSYYMAPER ISGGSYTISS DIWSLGLTLM EVALNRFPFP PEGSPPPMPI ELLSYIINMP
     PPLLPQEPGI KWSKSFQHFL CVCLDKDKTR RPGPQKMLTH PWVKAFERIH VDMEEFLRQV
     WSD
//

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