(data stored in ACNUC8465 zone)

HOGENOM: SCHPO_2_PE431

ID   SCHPO_2_PE431                        STANDARD;      PRT;   605 AA.
AC   SCHPO_2_PE431; P33886;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein kinase wis1; EC=2.7.12 2;AltName: Full=Protein
DE   kinase sty2; (SCHPO_2.PE431).
GN   Name=wis1; Synonyms=spc2, sty2; ORFNames=SPBC409.07c;
OS   SCHIZOSACCHAROMYCES POMBE.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SCHPO_2.PE431.
CC       Schizosaccharomyces pombe chromosome II EF1 full sequence 1..4539804
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:WIS1_SCHPO
CC   -!- FUNCTION: Dosage-dependent regulator of mitosis with serine/
CC       threonine protein kinase activity. May play a role in the
CC       integration of nutritional sensing with the control over entry
CC       into mitosis. It may interact with cdc25, wee1 and win1. May
CC       activate sty1.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- PTM: Dephosphorylated by pyp1 and pyp2.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Schizosaccharomyces_pombe;SPBC409.07C;SPBC409.07C-1;SPBC409.07C-1.
DR   UniProtKB/Swiss-Prot; P33886; -.
DR   EMBL; X62631; CAA44499.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAB52609.1; -; Genomic_DNA.
DR   PIR; S18648; S18648.
DR   RefSeq; NP_595457.1; NM_001021367.1.
DR   ProteinModelPortal; P33886; -.
DR   STRING; P33886; -.
DR   EnsemblFungi; SPBC409.07c-1; SPBC409.07c-1; SPBC409.07c.
DR   GeneID; 2541055; -.
DR   GenomeReviews; CU329671_GR; wis1.
DR   KEGG; spo:SPBC409.07c; -.
DR   NMPDR; fig|4896.1.peg.1323; -.
DR   GeneDB_Spombe; SPBC409.07c; -.
DR   eggNOG; fuNOG05342; -.
DR   GeneTree; EFGT00050000000597; -.
DR   OMA; DYHELAN; -.
DR   OrthoDB; EOG4RV60P; -.
DR   PhylomeDB; P33886; -.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-003522-MON; -.
DR   BRENDA; 2.7.12.2; 5615.
DR   ArrayExpress; P33886; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_Spombe.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_Spombe.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IGI:GeneDB_Spombe.
DR   GO; GO:0005515; F:protein binding; IPI:GeneDB_Spombe.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0051519; P:activation of bipolar cell growth; IMP:GeneDB_Spombe.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0070301; P:cellular response to hydrogen peroxide; IMP:GeneDB_Spombe.
DR   GO; GO:0070314; P:G1 to G0 transition; IMP:GeneDB_Spombe.
DR   GO; GO:0007067; P:mitosis; IEA:UniProtKB-KW.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:GeneDB_Spombe.
DR   GO; GO:0043555; P:regulation of translation in response to stress; IMP:GeneDB_Spombe.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IMP:GeneDB_Spombe.
DR   GO; GO:0006970; P:response to osmotic stress; TAS:GeneDB_Spombe.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; TAS:GeneDB_Spombe.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; SCHPO_2.PE431; -.
KW   SPBC409.07cccc7236820036002503210000011;
KW   P33886;
KW   ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase;
KW   Mitosis; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   605 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSPNNQPLS CSLRQLSISP TAPPGDVGTP GSLLSLSSSS SSNTDSSGSS LGSLSLNSNS
     SGSDNDSKVS SPSREIPSDP PLPRAVPTVR LGRSTSSRSR NSLNLDMKDP SEKPRRSLPT
     AAGQNNIGSP PTPPGPFPGG LSTDIQEKLK AFHASRSKSM PEVVNKISSP TTPIVGMGQR
     GSYPLPNSQL AGRLSNSPVK SPNMPESGLA KSLAAARNPL LNRPTSFNRQ TRIRRAPPGK
     LDLSNSNPTS PVSPSSMASR RGLNIPPTLK QAVSETPFST FSDILDAKSG TLNFKNKAVL
     NSEGVNFSSG SSFRINMSEI IKLEELGKGN YGVVYKALHQ PTGVTMALKE IRLSLEEATF
     NQIIMELDIL HKAVSPYIVD FYGAFFVEGS VFICMEYMDA GSMDKLYAGG IKDEGVLART
     AYAVVQGLKT LKEEHNIIHR DVKPTNVLVN SNGQVKLCDF GVSGNLVASI SKTNIGCQSY
     MAPERIRVGG PTNGVLTYTV QADVWSLGLT ILEMALGAYP YPPESYTSIF AQLSAICDGD
     PPSLPDSFSP EARDFVNKCL NKNPSLRPDY HELANHPWLL KYQNADVDMA SWAKGALKEK
     GEKRS
//

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