(data stored in SCRATCH zone)

HOGENOM: SEBTE_1_PE1002

ID   SEBTE_1_PE1002                       STANDARD;      PRT;   297 AA.
AC   SEBTE_1_PE1002; D1AFK5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1 61;AltName:
DE   Full=Hydroxymethylbilane synthase;AltName: Full=Pre-uroporphyrinogen
DE   synthase;Flags: Precursor; (SEBTE_1.PE1002).
GN   Name=hemC; OrderedLocusNames=Sterm_1022;
OS   SEBALDELLA TERMITIDIS ATCC 33386.
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Sebaldella.
OX   NCBI_TaxID=526218;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SEBTE_1.PE1002.
CC       Sebaldella termitidis ATCC 33386, complete genome.
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:D1AFK5_SEBTE
CC   -!- FUNCTION: Tetrapolymerization of the monopyrrole PBG into the
CC       hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4 porphobilinogen + H(2)O =
CC       hydroxymethylbilane + 4 NH(3).
CC   -!- COFACTOR: Binds 1 dipyrromethane group covalently (By similarity).
CC   -!- PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis;
CC       coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- MISCELLANEOUS: The porphobilinogen subunits are added to the
CC       dipyrromethane group (By similarity).
CC   -!- SIMILARITY: Belongs to the HMBS family.
CC   -!- GENE_FAMILY: HOG000228587 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D1AFK5; -.
DR   EMBL; CP001739; ACZ07890.1; -; Genomic_DNA.
DR   RefSeq; YP_003307821.1; NC_013517.1.
DR   GeneID; 8596501; -.
DR   GenomeReviews; CP001739_GR; Sterm_1022.
DR   KEGG; str:Sterm_1022; -.
DR   OMA; FKDVRGN; -.
DR   GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:HAMAP.
DR   GO; GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
DR   GO; GO:0006779; P:porphyrin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00260; Porphobil_deam; 1; -.
DR   InterPro; IPR000860; 4pyrrol_synth_OHMeBilane_synth.
DR   InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR   InterPro; IPR022417; Porphobilin_deaminase_N.
DR   InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR   Gene3D; G3DSA:3.30.160.40; Porphobil_deam; 1.
DR   PANTHER; PTHR11557; Porphobil_deam; 1.
DR   Pfam; PF01379; Porphobil_deam; 1.
DR   Pfam; PF03900; Porphobil_deamC; 1.
DR   PIRSF; PIRSF001438; 4pyrrol_synth_OHMeBilane_synth; 1.
DR   PRINTS; PR00151; PORPHBDMNASE.
DR   SUPFAM; SSF54782; Porphobil_deam; 1.
DR   TIGRFAMs; TIGR00212; HemC; 1.
DR   PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
DR   HOGENOMDNA; SEBTE_1.PE1002; -.
KW   Complete proteome; Porphyrin biosynthesis; Signal; Transferase.
SQ   SEQUENCE   297 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRKIVMGTRG SVLAVAQAET VKKMLIEKIP GLTVEIKKIV TSGDRDQTTN WGGDSSLKSM
     FVKEIERELL EGTIDFAVHS MKDMPQISPE GLINACFPIR EDNRDVLVSK NNTVFSEMPS
     GSVIGTSSLR RKSAVTELYP EMEIKPIRGN IHTRLGKLDS GEYDGIILAA AGLIRTGLES
     RISEYIDPEK MPPAPAQGIL CVQCRENNME ILEILKEIDD RETRIICEAE REFSRIFDGG
     CHTPMGCFAV IKEEEIFLKG MFCSGEKMYF GEAGGSIEKP KEAAQKLAEI IRRQINE
//

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