(data stored in ACNUC7421 zone)

HOGENOM: SHEVD_1_PE1005

ID   SHEVD_1_PE1005                       STANDARD;      PRT;   315 AA.
AC   SHEVD_1_PE1005; D4ZH27;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase;
DE   EC=1.17.1 2; (SHEVD_1.PE1005).
GN   Name=ispH; OrderedLocusNames=SVI_1005;
OS   SHEWANELLA VIOLACEA DSS12.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=637905;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SHEVD_1.PE1005.
CC       Shewanella violacea DSS12 chromosome, complete genome.
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:D4ZH27_SHEVD
CC   -!- FUNCTION: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CC       into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate
CC       (DMAPP) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + NAD(P)(+) + H(2)O
CC       = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H.
CC   -!- CATALYTIC ACTIVITY: Isopentenyl diphosphate + NAD(P)(+) + H(2)O =
CC       (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H.
CC   -!- COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
CC   -!- PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate
CC       biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-
CC       methylbutenyl diphosphate: step 1/1.
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate
CC       biosynthesis via DXP pathway; isopentenyl diphosphate from 1-
CC       deoxy-D-xylulose 5-phosphate: step 6/6.
CC   -!- SIMILARITY: Belongs to the IspH family.
CC   -!- GENE_FAMILY: HOG000220192 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D4ZH27; -.
DR   EMBL; AP011177; BAJ00976.1; -; Genomic_DNA.
DR   RefSeq; YP_003555754.1; NC_014012.1.
DR   GeneID; 8968389; -.
DR   GenomeReviews; AP011177_GR; SVI_1005.
DR   KEGG; svo:SVI_1005; -.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051745; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; IEA:HAMAP.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00191; IspH; 1; -.
DR   InterPro; IPR003451; LytB.
DR   Pfam; PF02401; LYTB; 1.
DR   TIGRFAMs; TIGR00216; IspH_lytB; 1.
DR   HOGENOMDNA; SHEVD_1.PE1005; -.
KW   3Fe-4S; Complete proteome; Iron; Iron-sulfur; Isoprene biosynthesis;
KW   Metal-binding; NADP; Oxidoreductase.
SQ   SEQUENCE   315 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNKPNSLQIK LANPRGFCAG VDRAISIVER ALELFSPPIY VRHEVVHNRY VVENLKDRGA
     VFVEELDQVP DDSIVIFSAH GVSQAVRAEA KRRGLKVFDA TCPLVTKVHL QVTRASRKGI
     ECILIGHAGH PEVEGTMGQY DNPKGGVLLV ESPEDVESME VKNPENLCFV TQTTLSMDDT
     ADIIAALQKR FPAIEGPRKD DICYATQNRQ DAVRNVADDV DLFIVVGSKN SSNSNRLREL
     AAKCGSEAYL VDNADDIDSS WFTNVTKVAV TAGASAPEVL VKQVIDAIAE LAPSVITEVE
     GRKEDTVFAV PAELR
//

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