(data stored in ACNUC7421 zone)

HOGENOM: SPISS_1_PE10

ID   SPISS_1_PE10                         STANDARD;      PRT;   388 AA.
AC   SPISS_1_PE10; E1R6N8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=S-adenosylmethionine synthase; Short=AdoMet synthase;
DE   EC=2.5.1 6;AltName: Full=MAT;AltName: Full=Methionine
DE   adenosyltransferase; (SPISS_1.PE10).
GN   Name=metK; OrderedLocusNames=Spirs_0010;
OS   SPIROCHAETA SMARAGDINAE DSM 11293.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Spirochaeta.
OX   NCBI_TaxID=573413;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SPISS_1.PE10.
CC       Spirochaeta smaragdinae DSM 11293 chromosome, complete genome.
CC       nt) ;
CC   -!- ANNOTATIONS ORIGIN:E1R6N8_SPISS
CC   -!- FUNCTION: Catalyzes the formation of S-adenosylmethionine from
CC       methionine and ATP (By similarity).
CC   -!- FUNCTION: Catalyzes the formation of S-adenosylmethionine from
CC       methionine and ATP. The overall synthetic reaction is composed of
CC       two sequential steps, AdoMet formation and the subsequent
CC       tripolyphosphate hydrolysis which occurs prior to release of
CC       AdoMet from the enzyme (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + L-methionine + H(2)O = phosphate +
CC       diphosphate + S-adenosyl-L-methionine.
CC   -!- COFACTOR: Binds 1 potassium ion per subunit (By similarity).
CC   -!- COFACTOR: Binds 2 divalent ions per subunit. Magnesium or cobalt
CC       (By similarity).
CC   -!- PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine
CC       biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the AdoMet synthase family.
CC   -!- GENE_FAMILY: HOG000245710 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E1R6N8; -.
DR   EMBL; CP002116; ADK79170.1; -; Genomic_DNA.
DR   RefSeq; YP_003801764.1; NC_014364.1.
DR   GeneID; 9488081; -.
DR   GenomeReviews; CP002116_GR; Spirs_0010.
DR   KEGG; ssm:Spirs_0010; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0004478; F:methionine adenosyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:HAMAP.
DR   GO; GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00086; S_AdoMet_synth1; 1; -.
DR   InterPro; IPR022631; ADOMET_SYNTHASE_CS.
DR   InterPro; IPR022630; S-AdoMet_synt_C.
DR   InterPro; IPR022629; S-AdoMet_synt_central.
DR   InterPro; IPR022628; S-AdoMet_synt_N.
DR   InterPro; IPR002133; S-AdoMet_synthetase.
DR   InterPro; IPR022636; S-AdoMet_synthetase_sfam.
DR   PANTHER; PTHR11964; S-AdoMet_synt; 1.
DR   Pfam; PF02773; S-AdoMet_synt_C; 1.
DR   Pfam; PF02772; S-AdoMet_synt_M; 1.
DR   Pfam; PF00438; S-AdoMet_synt_N; 1.
DR   PIRSF; PIRSF000497; MAT; 1.
DR   SUPFAM; SSF55973; S-AdoMet_synt; 3.
DR   TIGRFAMs; TIGR01034; MetK; 1.
DR   PROSITE; PS00376; ADOMET_SYNTHASE_1; 1.
DR   PROSITE; PS00377; ADOMET_SYNTHASE_2; 1.
DR   HOGENOMDNA; SPISS_1.PE10; -.
KW   S-adenosylmethionine synthetase;
KW   ATP-binding; Cobalt; Complete proteome; Cytoplasm; Magnesium;
KW   Metal-binding; Nucleotide-binding; One-carbon metabolism; Potassium;
KW   Transferase.
SQ   SEQUENCE   388 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDTKRKVLFT SESVSEGHPD KVCDQISDAV LDACLREDST SRVACETFTT TGMVLVGGEI
     STSTYVNLQD VVRGVVKRIG YDRPEYGLDW ESMAVIDTIH NQSSDISMGV TAGENKYKSQ
     GAGDQGMMFG FACNETEELM PAPIIFAHRL LQKAAAVRKS GECSWMRPDA KSQVTVQYEG
     GKPVRIDTIV ISHQHSPSVS IKEIEASLRK RVIEPVLGDT GLIDEKTRFF INPTGRFVIG
     GPHGDSGLTG RKIIVDTYGG MGRHGGGAFS GKDPSKVDRS AAYMARYVAK NIVAAGLCDR
     CELELSYAIG VPFPISVMVD TFGTATVPEE RIEAAVEKVF DLSPEGIIRE LGLLAPIYEA
     TAAYGHFGRD GFSWERVDKT EELKKAVG
//

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