(data stored in SCRATCH3701 zone)

HOGENOM6: SPISS_1_PE4218

ID   SPISS_1_PE4218                       STANDARD;      PRT;   818 AA.
AC   SPISS_1_PE4218; E1RA59;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (SPISS_1.PE4218).
GN   OrderedLocusNames=Spirs_4305;
OS   SPIROCHAETA SMARAGDINAE DSM 11293.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Spirochaeta.
OX   NCBI_TaxID=573413;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS SPISS_1.PE4218.
CC       Spirochaeta smaragdinae DSM 11293 chromosome, complete genome.
CC       nt) ;
CC   -!- ANNOTATIONS ORIGIN:E1RA59_SPISS
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E1RA59; -.
DR   EMBL; CP002116; ADK83378.1; -; Genomic_DNA.
DR   RefSeq; YP_003805972.1; NC_014364.1.
DR   GeneID; 9492434; -.
DR   GenomeReviews; CP002116_GR; Spirs_4305.
DR   KEGG; ssm:Spirs_4305; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; SPISS_1.PE4218; -.
DR   PRODOM; SPISS_1_PE4218.
DR   SWISS-2DPAGE; SPISS_1_PE4218.
KW   DNA gyrase, A subunit;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   818 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEEIKGQVIP ISIEEEVRGS YLNYAMSVIV SRALPDVRDG LKPVHRRILY SMNEMGLRSD
     RAFKKCGRIV GDVLGKYHPH GDQSIYDALV RLAQDFSMRY PVVRPQGNFG SVDGDPPAAM
     RYTEAKMDRV AEEMLKDIKK ETVDYGPNYD DSMQEPLVLP GAFPYLLTNG ASGIAVGMAT
     NMAPHNLREV CAAIVAYIND ANISIDDLMK YIKGPDFPTG GIIFGRRGIK QAFRTGKGKI
     TVRSKFVIET TKSGKDRIIV TEIPYAVNKA NLIVKIADLV KEKRIDGISD LRDESDRDGM
     RIVIELKRGT VPKVVLNQLF SHTALQQNFN VTNLALVDGM PKQLNLKELV HYFVRHRVEV
     VTRRTRYDLK KAEERAHILE GLKIALDNID EVVQIIKSSN DVNQARERLM ERFKLSERQS
     QAILDMRLQK LTSLETKKIE EELREVLALI AYLKDLLSSE QKILGVVRDE TEEIAQKYGD
     DRKTEIVADE VEEINIEDLI QKEDMVVLVS NKGFIKRVPV SSYRNQGRGG KGSSSAKLIN
     EDFIKHLFIA STHDYILFVT NEGKAYWMKV HEIPEGSRAS RGTHIKALLE ISANEDITTI
     VSLQEFSEEH YLFMATARGI VKKVKTSDFR NARTRGIIAI KLDNGDTLIT AVLTRGDSEI
     VIVSRNGNAL RFHEDQVRAM GRASRGVTGI RLQSDDELAG ILRVEDNEKM LLLSENGLGK
     RVEYDHFSLH GRGTRGQIAY KTSERSGEIV GVLSVLEEDD LVCITSQGNT IKLHVSDVPV
     QGKTAQGVNI VTITAPDVVV DVARVMNDKD EEEDQPQA
//

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