(data stored in ACNUC7421 zone)

HOGENOM: STAAN_1_PE1006

ID   STAAN_1_PE1006                       STANDARD;      PRT;   645 AA.
AC   STAAN_1_PE1006; Q7A656;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Iron-regulated surface determinant protein B;AltName:
DE   Full=Fur-regulated protein B;AltName: Full=Staphylococcal iron-regulated
DE   protein H;AltName: Full=Staphylococcus aureus surface protein J;Flags:
DE   Precursor; (STAAN_1.PE1006).
GN   Name=isdB; Synonyms=frpB, sasJ, sirH; OrderedLocusNames=SA0976;
OS   STAPHYLOCOCCUS AUREUS SUBSP. AUREUS N315.
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STAAN_1.PE1006.
CC       Staphylococcus aureus subsp. aureus N315, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:ISDB_STAAN
CC   -!- FUNCTION: Seems to function as the primary receptor for hemoglobin
CC       since its inactivation inhibits the ability of S.aureus to bind
CC       hemoglobin. Binds hemoglobin in a dose-dependent way. Required for
CC       S.aureus growth using hemoglobin as the sole iron source. Also
CC       required for virulence. IsdA and/or isdB promote resistance to
CC       hydrogen peroxide and killing by neutrophils (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall; Peptidoglycan-anchor
CC       (By similarity).
CC   -!- INDUCTION: Repressed by fur in the presence of iron (By
CC       similarity).
CC   -!- BIOTECHNOLOGY: A combined vaccine containing isdA, isdB, sdrD and
CC       sdrE afforded significative protection in mice against a lethal
CC       challenge with S.aureus Newman or any of the clinical isolates
CC       NRS252, N315, NRS248, USA100 and USA400. The immune response
CC       elicited by the combined vaccine is greater than the one elicited
CC       by its individual components.
CC   -!- SIMILARITY: Belongs to the isdB family.
CC   -!- SIMILARITY: Contains 2 NEAT domains.
CC   -!- GENE_FAMILY: HOG000280077 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q7A656; -.
DR   EMBL; BA000018; BAB42225.1; -; Genomic_DNA.
DR   PIR; E89883; E89883.
DR   RefSeq; NP_374246.1; NC_002745.2.
DR   PDB; 3RTL; X-ray; 1.45 A; A/B/C/D=341-459.
DR   PDB; 3RUR; X-ray; 1.70 A; A/B/C/D=341-459.
DR   PDBsum; 3RTL; -.
DR   PDBsum; 3RUR; -.
DR   ProteinModelPortal; Q7A656; -.
DR   SMR; Q7A656; 342-452.
DR   STRING; Q7A656; -.
DR   EnsemblBacteria; EBSTAT00000000528; EBSTAP00000000528; EBSTAG00000000528.
DR   GeneID; 1123803; -.
DR   GenomeReviews; BA000018_GR; SA0976.
DR   KEGG; sau:SA0976; -.
DR   GeneTree; EBGT00050000023708; -.
DR   OMA; ANADKTN; -.
DR   ProtClustDB; CLSK885152; -.
DR   BioCyc; SAUR158879:SA0976-MON; -.
DR   GO; GO:0009986; C:cell surface; IEA:InterPro.
DR   GO; GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR005877; Gpos_YSIRK.
DR   InterPro; IPR019948; Gram-positive_anchor.
DR   InterPro; IPR019929; Haem_uptake_protein_IsdB.
DR   InterPro; IPR019931; LPXTG-motif_cell_wall_anchor.
DR   InterPro; IPR006635; NEA_transpt.
DR   InterPro; IPR001899; Surface_protein_Gram_pos_cocci.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF05031; NEAT; 2.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SMART; SM00725; NEAT; 2.
DR   TIGRFAMs; TIGR03657; IsdB; 1.
DR   TIGRFAMs; TIGR01167; LPXTG_anchor; 1.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR   PROSITE; PS50978; NEAT; 2.
DR   HOGENOMDNA; STAAN_1.PE1006; -.
KW   hypothetical protein;
KW   3D-structure; Cell wall; Complete proteome; Iron; Metal-binding;
KW   Peptidoglycan-anchor; Repeat; Secreted; Signal; Virulence.
SQ   SEQUENCE   645 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNKQQKEFKS FYSIRKSSLG VASVAISTLL LLMSNGEAQA AAEETGGTNT EAQPKTEAVA
     SPTTTSEKAP ETKPVANAVS VSNKEVEAPT SETKEAKEVK EVKAPKETKA VKPAAKATNN
     TYPILNQELR EAIKNPAIKD KDHSAPNSRP IDFEMKKENG EQQFYHYASS VKPARVIFTD
     SKPEIELGLQ SGQFWRKFEV YEGDKKLPIK LVSYDTVKDY AYIRFSVSNG TKAVKIVSST
     HFNNKEEKYD YTLMEFAQPI YNSADKFKTE EDYKAEKLLA PYKKAKTLER QVYELNKIQD
     KLPEKLKAEY KKKLEDTKKA LDEQVKSAIT EFQNVQPTNE KMTDLQDTKY VVYESVENNE
     SMMDTFVKHP IKTGMLNGKK YMVMETTNDD YWKDFMVEGQ RVRTISKDAK NNTRTIIFPY
     VEGKTLYDAI VKVHVKTIDY DGQYHVRIVD KEAFTKANTD KSNKKEQQDN SAKKEATPAT
     PSKPTPSPVE KESQKQDSQK DDNKQLPSVE KENDASSESG KDKTPATKPT KGEVESSSTT
     PTKVVSTTQN VAKPTTASSK TTKDVVQTSA GSSEAKDSAP LQKANIKNTN DGHTQSQNNK
     NTQENKAKSL PQTGEESNKD MTLPLMALLA LSSIVAFVLP RKRKN
//

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