(data stored in ACNUC7421 zone)

HOGENOM: STAAN_1_PE1008

ID   STAAN_1_PE1008                       STANDARD;      PRT;   227 AA.
AC   STAAN_1_PE1008; Q7A654;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Iron-regulated surface determinant protein C;AltName:
DE   Full=Staphylococcal iron-regulated protein D;Flags: Precursor;
DE   (STAAN_1.PE1008).
GN   Name=isdC; Synonyms=sirD; OrderedLocusNames=SA0978;
OS   STAPHYLOCOCCUS AUREUS SUBSP. AUREUS N315.
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STAAN_1.PE1008.
CC       Staphylococcus aureus subsp. aureus N315, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:ISDC_STAAN
CC   -!- FUNCTION: Involved in heme (porphyrin) scavenging. Binds
CC       hemoglobin and almost exclusively free-base protoporphyrin IX.
CC       Probably has a role as the central conduit of the isd heme uptake
CC       system, i.e., mediates the transfer of the iron-containing
CC       nutrient from isdABH to the membrane translocation system isdDEF.
CC       Hemin-free isdC (apo-isdC) acquires hemin from hemin-containing
CC       isdA (holo-isdA) probably through the activated holo-isdA-apo-isdC
CC       complex and due to the higher affinity of apo-isdC for the
CC       cofactor. The reaction is reversible (By similarity).
CC   -!- SUBUNIT: Monomer. Interacts with isdA (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall; Peptidoglycan-anchor
CC       (By similarity).
CC   -!- INDUCTION: Repressed by fur in the presence of iron (By
CC       similarity).
CC   -!- DOMAIN: The NEAT domain binds Fe(3+) heme iron. Reduction of the
CC       high-spin Fe(3+) heme iron to high-spin Fe(2+) results in loss of
CC       the heme from the binding site of the protein due to the absence
CC       of a proximal histidine (By similarity).
CC   -!- SIMILARITY: Belongs to the isdC family.
CC   -!- SIMILARITY: Contains 1 NEAT domain.
CC   -!- GENE_FAMILY: HOG000059157 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q7A654; -.
DR   EMBL; BA000018; BAB42227.1; -; Genomic_DNA.
DR   PIR; G89883; G89883.
DR   RefSeq; NP_374248.1; NC_002745.2.
DR   ProteinModelPortal; Q7A654; -.
DR   SMR; Q7A654; 25-149.
DR   STRING; Q7A654; -.
DR   EnsemblBacteria; EBSTAT00000001676; EBSTAP00000001676; EBSTAG00000001676.
DR   GeneID; 1123805; -.
DR   GenomeReviews; BA000018_GR; SA0978.
DR   KEGG; sau:SA0978; -.
DR   eggNOG; COG5386; -.
DR   GeneTree; EBGT00050000023721; -.
DR   OMA; MPYGKVS; -.
DR   ProtClustDB; CLSK885154; -.
DR   BioCyc; SAUR158879:SA0978-MON; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; IEA:InterPro.
DR   GO; GO:0030492; F:hemoglobin binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0015886; P:heme transport; IEA:InterPro.
DR   InterPro; IPR019909; Haem_uptake_protein_IsdC.
DR   InterPro; IPR006635; NEA_transpt.
DR   InterPro; IPR017505; Sortase_SrtB_sig_NPQTN.
DR   Pfam; PF05031; NEAT; 1.
DR   SMART; SM00725; NEAT; 1.
DR   TIGRFAMs; TIGR03656; IsdC; 1.
DR   TIGRFAMs; TIGR03068; SrtB_sig_NPQTN; 1.
DR   PROSITE; PS50978; NEAT; 1.
DR   HOGENOMDNA; STAAN_1.PE1008; -.
KW   hypothetical protein;
KW   Cell wall; Complete proteome; Heme; Iron; Metal-binding;
KW   Peptidoglycan-anchor; Secreted; Signal.
SQ   SEQUENCE   227 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKNILKVFNT TILALIIIIA TFSNSANAAD SGTLNYEVYK YNTNDTSIAN DYFNKPAKYI
     KKNGKLYVQI TVNHSHWITG MSIEGHKENI ISKNTAKDER TSEFEVSKLN GKIDGKIDVY
     IDEKVNGKPF KYDHHYNITY KFNGPTDVAG ANAPGKDDKN SASGSDKGSD GTTTGQSESN
     SSNKDKVENP QTNAGTPAYI YAIPVASLAL LIAITLFVRK KSKGNVE
//

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