(data stored in ACNUC7421 zone)

HOGENOM: STAAS_1_PE1005

ID   STAAS_1_PE1005                       STANDARD;      PRT;   88 AA.
AC   STAAS_1_PE1005; Q6GAD1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Phosphocarrier protein HPr; EC=2.7.11 -;AltName:
DE   Full=Histidine-containing protein; (STAAS_1.PE1005).
GN   Name=ptsH; OrderedLocusNames=SAS1018;
OS   STAPHYLOCOCCUS AUREUS SUBSP. AUREUS MSSA476.
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STAAS_1.PE1005.
CC       Staphylococcus aureus subsp. aureus MSSA476 chromosome, complete genome
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:PTHP_STAAS
CC   -!- FUNCTION: General (non sugar-specific) component of the
CC       phosphoenolpyruvate-dependent sugar phosphotransferase system
CC       (sugar PTS). This major carbohydrate active-transport system
CC       catalyzes the phosphorylation of incoming sugar substrates
CC       concomitantly with their translocation across the cell membrane.
CC       The phosphoryl group from phosphoenolpyruvate (PEP) is transferred
CC       to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr
CC       then transfers it to the permease (enzymes II/III) (By
CC       similarity).
CC   -!- FUNCTION: P-Ser-HPr interacts with the catabolite control protein
CC       A (CcpA), forming a complex that binds to DNA at the catabolite
CC       response elements cre, operator sites preceding a large number of
CC       catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in
CC       carbon catabolite repression (CCR), a mechanism that allows
CC       bacteria to coordinate and optimize the utilization of available
CC       carbon sources. P-Ser-HPr also plays a role in inducer exclusion,
CC       in which it probably interacts with several non-PTS permeases and
CC       inhibits their transport activity (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protein HPr N(pi)-phospho-L-histidine +
CC       protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L-
CC       histidine.
CC   -!- ENZYME REGULATION: Phosphorylation on Ser-46 inhibits the
CC       phosphoryl transfer from enzyme I to HPr (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Contains 1 HPr domain.
CC   -!- GENE_FAMILY: HOG000278399 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q6GAD1; -.
DR   EMBL; BX571857; CAG42792.1; -; Genomic_DNA.
DR   RefSeq; YP_043142.1; NC_002953.3.
DR   ProteinModelPortal; Q6GAD1; -.
DR   SMR; Q6GAD1; 1-88.
DR   STRING; Q6GAD1; -.
DR   EnsemblBacteria; EBSTAT00000024233; EBSTAP00000023400; EBSTAG00000024232.
DR   GeneID; 2863067; -.
DR   GenomeReviews; BX571857_GR; SAS1018.
DR   KEGG; sas:SAS1018; -.
DR   eggNOG; COG1925; -.
DR   GeneTree; EBGT00050000025089; -.
DR   OMA; NDKFHEE; -.
DR   ProtClustDB; PRK13780; -.
DR   BioCyc; SAUR282459:SAS1018-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR001020; PTS_HPr_His_P_site.
DR   InterPro; IPR005698; PTS_HPr_prot.
DR   InterPro; IPR000032; PTS_HPr_prot-like.
DR   InterPro; IPR002114; PTS_HPr_Ser_P_site.
DR   Gene3D; G3DSA:3.30.1340.10; PTS_HPr_protein; 1.
DR   Pfam; PF00381; PTS-HPr; 1.
DR   PRINTS; PR00107; PHOSPHOCPHPR.
DR   SUPFAM; SSF55594; HPr_protein; 1.
DR   TIGRFAMs; TIGR01003; PTS_HPr_family; 1.
DR   PROSITE; PS51350; PTS_HPR_DOM; 1.
DR   PROSITE; PS00369; PTS_HPR_HIS; 1.
DR   PROSITE; PS00589; PTS_HPR_SER; 1.
DR   HOGENOMDNA; STAAS_1.PE1005; -.
KW   phosphocarrier protein HPr;
KW   Complete proteome; Cytoplasm; Kinase; Phosphoprotein;
KW   Phosphotransferase system; Sugar transport; Transcription;
KW   Transcription regulation; Transferase; Transport.
SQ   SEQUENCE   88 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEQNSYVIID ETGIHARPAT MLVQTASKFD SDIQLEYNGK KVNLKSIMGV MSLGVGKDAE
     ITIYADGSDE SDAIQAISDV LSKEGLTK
//

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