(data stored in SCRATCH3701 zone)

HOGENOM6: STAEQ_1_PE2488

ID   STAEQ_1_PE2488                       STANDARD;      PRT;   893 AA.
AC   STAEQ_1_PE2488; Q5HK04;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA gyrase subunit A; EC=5.99.1 3; (STAEQ_1.PE2488).
GN   Name=gyrA; OrderedLocusNames=SERP2548;
OS   STAPHYLOCOCCUS EPIDERMIDIS RP62A.
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STAEQ_1.PE2488.
CC       Staphylococcus epidermidis RP62A, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:GYRA_STAEQ
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q5HK04; -.
DR   EMBL; CP000029; AAW53372.1; -; Genomic_DNA.
DR   RefSeq; YP_190089.1; NC_002976.3.
DR   ProteinModelPortal; Q5HK04; -.
DR   SMR; Q5HK04; 31-489.
DR   STRING; Q5HK04; -.
DR   EnsemblBacteria; EBSTAT00000041598; EBSTAP00000040141; EBSTAG00000041596.
DR   GeneID; 3242531; -.
DR   GenomeReviews; CP000029_GR; SERP2548.
DR   KEGG; ser:SERP2548; -.
DR   NMPDR; fig|176279.3.peg.1682; -.
DR   TIGR; SERP2548; -.
DR   eggNOG; COG0188; -.
DR   GeneTree; EBGT00050000024676; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   BioCyc; SEPI176279:SERP2548-MON; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   HAMAP; MF_01897; GyrA; 1; -.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; STAEQ_1.PE2488; -.
DR   PRODOM; STAEQ_1_PE2488.
DR   SWISS-2DPAGE; STAEQ_1_PE2488.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   893 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAELPQSRIN ERNITSEMRE SFLDYAMSVI VSRALPDVRD GLKPVHRRIL YGLNEQGMTP
     DKPYKKSARI VGDVMGKYHP HGDSSIYEAM VRMAQDFSYR YPLVDGQGNF GSMDGDGAAA
     MRYTEARMTK ITLELLRDIN KDTIDFIDNY DGNEREPSVL PARFPNLLVN GAAGIAVGMA
     TNIPPHNLTE VIDGVLSLSK NPDITINELM EDIQGPDFPT AGLVLGKSGI RRAYETGRGS
     IQMRSRAEIE ERGGGRQRIV VTEIPFQVNK ARMIEKIAEL VRDKKIDGIT DLRDETSLRT
     GVRVVIDVRK DANASVILNN LYKQTPLQTS FGVNMIALVN SRPKLINLKE ALIHYLEHQK
     TVVRRRTEYN LKKARDRAHI LEGLRIALDH IDEIITTIRE SDTDKIAMAS LQERFKLTER
     QAQAILDMRL RRLTGLERDK IESEYNELLE YIKELEEILA DEEVLLQLVR DELTEIKERF
     GDERRTEIQL GGLEDLEDED LIPEEQIVIT LSHNNYIKRL PVSTYRSQNR GGRGIQGMNT
     LDEDFVSQLV TMSTHDHVLF FTNKGRVYKL KGYEVPELSR QSKGIPIINA IELENDETIS
     TMIAVKDLES EEDYLVFATK QGIVKRSSLS NFSRINKNGK IAINFKEDDE LIAVRLTTGN
     EDILIGTAHA SLIRFSESTL RPLGRTAAGV KGISLREGDT VVGLDVADSE SEDEVLVVTE
     NGYGKRTPVS EYRLSNRGGK GIKTATITER NGNIVCITTV TGEEDLMVVT NAGVIIRLDV
     HDISQNGRAA QGVRLMKLGD GQFVSTVAKV NEEDDNEENA DEAQQSTTTE TADVEEVVDD
     QTPGNAIHTE GDAEMESVES PENDDRIDIR QDFMDRVNED IESASDNEED SDE
//

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