(data stored in SCRATCH3701 zone)

HOGENOM6: STAVE1_1_PE4329

ID   STAVE1_1_PE4329                      STANDARD;      PRT;   864 AA.
AC   STAVE1_1_PE4329; Q82FD2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Putative DNA gyrase subunit A; (STAVE1_1.PE4329).
GN   Name=gyrA; OrderedLocusNames=SAV4322; ORFNames=SAV_4322;
OS   STREPTOMYCES AVERMITILIS MA-4680.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STAVE1_1.PE4329.
CC       Streptomyces avermitilis MA-4680, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:Q82FD2_STRAW
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q82FD2; -.
DR   EMBL; BA000030; BAC72034.1; -; Genomic_DNA.
DR   RefSeq; NP_825499.1; NC_003155.4.
DR   HSSP; P09097; 1AB4.
DR   ProteinModelPortal; Q82FD2; -.
DR   GeneID; 1210952; -.
DR   GenomeReviews; BA000030_GR; SAV4322.
DR   KEGG; sma:SAV_4322; -.
DR   NMPDR; fig|227882.1.peg.4325; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   BioCyc; SAVE227882:SAV4322-MONOMER; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; STAVE1_1.PE4329; -.
DR   PRODOM; STAVE1_1_PE4329.
DR   SWISS-2DPAGE; STAVE1_1_PE4329.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   864 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDENTPSTP EEEGEIALRV EPVGLETEMQ RSYLDYAMSV IVSRALPDVR DGLKPVHRRV
     LYAMYDGGYR PEKGFYKCAR VVGDVMGNYH PHGDSSIYDA LVRLAQPWSM RMPLVDSNGN
     FGSPGNDPAA AMRYTECKMM PLSMEMVRDI DEETVDFTDN YDGRSQEPTV LPARFPNLLI
     NGSAGIAVGM ATNIPPHNLR EVASGAQWYL ENPEASHEEL LDALIERIKG PDFPSGALVV
     GRKGIEEAYR TGRGSITMRA VVEVEEIQNR QCLVVTELPY QVNPDNLAQK IADLVKDGKV
     GGIADVRDET SSRTGQRLVI VLKRDAVAKV VLNNLYKHTD LQTNFGANML ALVDGVPRTL
     SLDAFIRHWV THQIEVIVRR TKFRLRKAEE RAHILRGLLK ALDAIDEVIA LIRRSDTVEI
     AREGLMGLLE IDEIQANAIL EMQLRRLAAL ERQKIIQEHD ELQAKITEYN AILASPVRQR
     GIISEELAAI VEKYGDDRRS KLVPFDGDMS IEDLIAEEDI VVTITRGGYI KRTKTEDYRS
     QKRGGKGVRG TKLKQDDIVD HFFVSTTHHW LLFFTNKGRV YRAKAYELPD AGRDARGQHV
     ANLLAFQPDE AIAEILAIRD YEAVPYLVLA TKGGLVKKTP LKDYDSPRSG GVIAINLRET
     EDGSDDELIG AELVSAEDDL LLISKKAQSI RFTATDEALR PMGRATSGVK GMSFREGDEL
     LSMNVVRPGT FVFTATDGGY AKRTAVDEYR VQGRGGLGIK AAKIVEDRGS LVGALVVEET
     DEILAITLSG GVIRTRVNEV RETGRDTMGV QLINLGKRDA VVGIARNAEA GREAEEVDGG
     DAVDETTEGI EAAGTDEGEQ SSDE
//

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