(data stored in ACNUC30630 zone)

HOGENOM: STCOE1_1_PE3174

ID   STCOE1_1_PE3174                      STANDARD;      PRT;   511 AA.
AC   STCOE1_1_PE3174; Q9Z4W7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (STCOE1_1.PE3174).
GN   Name=trpE; OrderedLocusNames=SCO3214; ORFNames=SCE8.07c;
OS   STREPTOMYCES COELICOLOR A3(2).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=100226;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STCOE1_1.PE3174.
CC       Streptomyces coelicolor A3(2) chromosome, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:TRPE_STRCO
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q9Z4W7; -.
DR   EMBL; AL939115; CAB38585.1; -; Genomic_DNA.
DR   PIR; T36306; T36306.
DR   RefSeq; NP_627428.1; NC_003888.3.
DR   ProteinModelPortal; Q9Z4W7; -.
DR   GeneID; 1098648; -.
DR   GenomeReviews; AL645882_GR; SCO3214.
DR   KEGG; sco:SCO3214; -.
DR   NMPDR; fig|100226.1.peg.3174; -.
DR   OMA; HEYKESF; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   HOGENOMDNA; STCOE1_1.PE3174; -.
KW   anthranilate synthase component I;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Reference proteome; Tryptophan biosynthesis.
SQ   SEQUENCE   511 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTTHAAEAPT TDPQGAPGSQ KTPDATEAEE AARATVPHRA AAAALAREHD VVPLHQEFLD
     DSVSPVTAFA QLCGPDEAGF LLESVPVSGG VARYSYVGHR PVPLEPTGGD PLTALRSHLA
     RSVAPVPGLP PFHGGVVGYL GYEAARHFED LPLAAGPPPG LPESAFLAAD DLVVFDHATR
     RVLLMTLYRP ARESYDDAVA RIVRLNRALR RAPAPAAFSG RPLAAATPAD HGTQGWTANL
     TEAQFTERVA RAREHIAAGD AFQIVLSRRL SRPLRARPTD LYRHLRATNP SPYMYHLSLG
     GGRHVIGASP ELLVKAEGRT VRTRPLAGTR PRHPDPAEDL RLERELRADE KERAEHVMLV
     DLGRNDLGRV TEPGTVRVER LMRVERFSHV MHLSSTVRGR LAEGRDALDA LRSAFPAGTL
     SGAPKIRAME IIAELEPEQR GVYGGALGFV GADGLTDFAI ALRTMVVADG HVHVQAGAGI
     VADSDPAAEF RETLHKSRAM LTAVRRAEAA A
//

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