(data stored in SCRATCH3701 zone)

HOGENOM6: STCOE1_1_PE3829

ID   STCOE1_1_PE3829                      STANDARD;      PRT;   857 AA.
AC   STCOE1_1_PE3829; P35885; Q9KXX5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA gyrase subunit A; EC=5.99.1 3; (STCOE1_1.PE3829).
GN   Name=gyrA; OrderedLocusNames=SCO3873; ORFNames=SCH18.10c;
OS   STREPTOMYCES COELICOLOR A3(2).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=100226;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STCOE1_1.PE3829.
CC       Streptomyces coelicolor A3(2) chromosome, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:GYRA_STRCO
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings.
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA65216.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P35885; Q9KXX5; -.
DR   EMBL; L27063; AAA65216.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL939118; CAB92993.1; -; Genomic_DNA.
DR   RefSeq; NP_628060.1; NC_003888.3.
DR   ProteinModelPortal; P35885; -.
DR   GeneID; 1099309; -.
DR   GenomeReviews; AL645882_GR; SCO3873.
DR   KEGG; sco:SCO3873; -.
DR   NMPDR; fig|100226.1.peg.3830; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009330; C:DNA topoisomerase complex (ATP-hydrolyzing); ISS:RefGenome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; ISS:RefGenome.
DR   GO; GO:0008094; F:DNA-dependent ATPase activity; ISS:RefGenome.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007059; P:chromosome segregation; ISS:RefGenome.
DR   GO; GO:0006265; P:DNA topological change; ISS:RefGenome.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; ISS:RefGenome.
DR   HAMAP; MF_01897; GyrA; 1; -.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; STCOE1_1.PE3829; -.
DR   PRODOM; STCOE1_1_PE3829.
DR   SWISS-2DPAGE; STCOE1_1_PE3829.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Reference proteome; Topoisomerase.
SQ   SEQUENCE   857 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTTPEGDALA MRVEPVGLET EMQRSYLDYA MSVIVSRALP DVRDGLKPVH RRVLYAMYDG
     GYRPERGFYK CARVVGDVMG NYHPHGDSSI YDALVRLAQP WSMRMPLVDS NGNFGSPGND
     PAAAMRYTEC KMAPLSMEMV RDIDEETVDF TDNYDGRSQE PTVLPARFPN LLINGSAGIA
     VGMATNIPPH NLREVAAGAQ WYLENYEASH EELLDALIER IKGPDFPTGA LVVGRKGIEE
     AYRTGRGSIT MRAVVEVEEI QNRQCLVVTE LPYQTNPDNL AQKIADLVKD GKVGGIADVR
     DETSSRTGQR LVIVLKRDAV AKVVLNNLYK HTDLQSNFGA NMLALVDGVP RTLSLDAFIR
     HWVNHQIEVI VRRTRFRLRK AEERAHILRG LLKALDAIDE VIALIRRSDT VEIARGGLMD
     LLEIDEIQAN AILEMQLRRL AALERQKIVR EHDELQAKIT EYNEILASPV RQRGIVSEEL
     TALVEKYGDD RKTKLIPYEG DMSIEDLIAE EDIVVTVTRG GYIKRTKTDD YRAQKRGGKG
     VRGTKLKEDD IVNHFFVSTT HHWLLFFTNK GRVYRAKAYE LPDAGRDARG QHVANLLAFQ
     PDETIAQIRA IRDYEAVPYL VLATKAGLVK KTPLKDYDSP RSGGVIAINL REQADGSDDE
     LIGAELVSAE DDLLLISKKA QSIRFTASDD TLRPMGRATS GVKGMSFREG DELLSMNVVR
     AGTFVFTATD GGYAKRTSVD EYRVQGRGGL GIKAAKIVED RGSLVGALVV EEHDEILAIT
     LSGGVIRTRV NGVRETGRDT MGVQLINLGK RDAVVGIARN AEAGREAEEV DGDVAVDETA
     EGAATTGTDE GEAPSAE
//

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