(data stored in ACNUC1104 zone)

HOGENOM: STCOE1_2_PE237

ID   STCOE1_2_PE237                       STANDARD;      PRT;   475 AA.
AC   STCOE1_2_PE237; P11545;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylenomycin A resistance protein;AltName: Full=MMR
DE   peptide; (STCOE1_2.PE237).
GN   Name=mmr; OrderedLocusNames=SCP1.237c;
OS   STREPTOMYCES COELICOLOR A3(2).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=100226;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STCOE1_2.PE237.
CC       Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:MMR_STRCO
CC   -!- FUNCTION: Resistance to the epoxide antibiotic methylenomycin A;
CC       probably by mediating its efflux.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC   -!- GENE_FAMILY: HOG000239124 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P11545; -.
DR   EMBL; M18263; AAA98341.1; -; Genomic_DNA.
DR   EMBL; AJ276673; CAB82871.1; -; Genomic_DNA.
DR   EMBL; AL589148; CAC36763.1; -; Genomic_DNA.
DR   PIR; B29606; B29606.
DR   RefSeq; NP_639847.1; NC_003903.1.
DR   ProteinModelPortal; P11545; -.
DR   GeneID; 1095320; -.
DR   GenomeReviews; AL589148_GR; SCP1.237c.
DR   KEGG; sco:SCP1.237c; -.
DR   NMPDR; fig|100226.1.peg.8006; -.
DR   OMA; MATLDVT; -.
DR   ProtClustDB; CLSK570800; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS_gen_substrate_transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   HOGENOMDNA; STCOE1_2.PE237; -.
KW   methylenomycin a resistance protein, mmr;
KW   Antibiotic resistance; Cell membrane; Complete proteome; Membrane;
KW   Plasmid; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
SQ   SEQUENCE   475 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTTVRTGGAQ TAEVPAGGRR DVPSGVKITA LATGFVMATL DVTVVNVAGA TIQESLDTTL
     TQLTWIVDGY VLTFASLLML AGGLANRIGA KTVYLWGMGV FFLASLACAL APTAETLIAA
     RLVQGAGAAL FMPSSLSLLV FSFPEKRQRT RMLGLWSAIV ATSSGLGPTV GGLMVSAFGW
     ESIFLLNLPI GAIGMAMTYR YIAATESRAT RLAVPGHLLW IVALAAVSFA LIEGPQLGWT
     AGPVLTAYAV AVTAAALLAL REHRVTNPVM PWQLFRGPGF TGANLVGFLF NFALFGSTFM
     LGLYFQHARG ATPFQAGLEL LPMTIFFPVA NIVYARISAR FSNGTLLTAF LLLAGAASLS
     MVTITASTPY WVVAVAVGVA NIGAGIISPG MTAALVDAAG PENANVAGSV LNANRQIGSL
     VGIAAMGVVL HSTSDWDHGA AISFLAVGLA YLLGGLSAWR LIARPERRSA VTAAT
//

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