(data stored in ACNUC7421 zone)

HOGENOM: STPYO2_1_PE1005

ID   STPYO2_1_PE1005                      STANDARD;      PRT;   1036 AA.
AC   STPYO2_1_PE1005; Q8P0S5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA polymerase III subunit alpha; EC=2.7.7 7;
DE   (STPYO2_1.PE1005).
GN   Name=dnaE; OrderedLocusNames=spyM18_1232;
OS   STREPTOCOCCUS PYOGENES MGAS8232.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
OX   NCBI_TaxID=186103;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS STPYO2_1.PE1005.
CC       Streptococcus pyogenes MGAS8232, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:DPO3A_STRP8
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria.
CC       This DNA polymerase also exhibits 3' to 5' exonuclease activity.
CC       The alpha chain is the DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha,
CC       epsilon and theta chains) that associates with a tau subunit. This
CC       core dimerizes to form the PolIII' complex. PolIII' associates
CC       with the gamma complex (composed of gamma, delta, delta', psi and
CC       chi chains) and with the beta chain to form the complete DNA
CC       polymerase III complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE
CC       subfamily.
CC   -!- GENE_FAMILY: HOG000021785 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q8P0S5; -.
DR   EMBL; AE009949; AAL97842.1; -; Genomic_DNA.
DR   RefSeq; NP_607343.1; NC_003485.1.
DR   ProteinModelPortal; Q8P0S5; -.
DR   EnsemblBacteria; EBSTRT00000029753; EBSTRP00000028675; EBSTRG00000029753.
DR   GeneID; 994375; -.
DR   GenomeReviews; AE009949_GR; spyM18_1232.
DR   KEGG; spm:spyM18_1232; -.
DR   GeneTree; EBGT00050000027831; -.
DR   OMA; IHQMGFD; -.
DR   ProtClustDB; PRK07279; -.
DR   BioCyc; SPYO186103:SPYM18_1232-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA-helicase.
DR   InterPro; IPR004013; PHP_C.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; Polc; 1.
DR   HOGENOMDNA; STPYO2_1.PE1005; -.
KW   Complete proteome; Cytoplasm; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
SQ   SEQUENCE   1036 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFAQLDTKTV YSFMDSLIDL NHYFERAKQF GYHTIGIMDK DNLYGAYHFI KGCQKNGLQP
     VLGLEVEILY QERQVLLNLI AQNTQGYHQL LKISTAKMSG KLHMDYLCQH LEGIAVIIPS
     KGWSDTLVVP FDYYIGVDQY TDLSHMDSKR QLIPLRTVRY FAQDDMETLH MLHAIRDNLS
     LAETPVVESD QELADCQQLT TFYQTHCPQA LQNLEDLVSG IYYDFDTNLK LPHFNRDKSA
     KQELQDLTEA GLKEKGLWKE PYQSRLLHEL VIISDMGFDD YFLIVWDLLR FGRSKGYYMG
     MGRGSAAGSL VAYALDITGI DPVQHDLLFE RFLNKERYSM PDIDIDLPDI YRSEFLRYVR
     NRYGSDHSAQ IVTFSTFGPK QAIRDVFKRF GVPEYELTNL TKKIGFKDSL ATVYEKSISF
     RQVINSRTEF QKAFAIAKRI EGNPRQTSIH AAGIVMSDDT LTNHIPLKSG DDMMITQYDA
     HAVEANGLLK MDFLGLRNLT FVQKMQEKVA KDYGCQIDIA AIDLEDPQTL ALFAKGDTKG
     IFQFEQNGAI NLLKRIKPQR FEEIVATTSL NRPGASDYTT NFIKRREGQE KIDLIDPVIA
     PILEPTYGIM LYQEQVMQIA QVYAGFTLGK ADLLRRAMSK KNLQEMQKME EDFIASAKHL
     GRAEETARGL FKRMEKFAGY GFNRSHAFAY SALAFQLAYF KAHYPAVFYD IMMNYSSSDY
     ITDALESDFQ VAQVTINSIP YTDKIEASKI YMGLKNIKGL PRDFAYWIIE QRPFNSVEDF
     LTRTPEKYQK KVFLEPLIKI GLFDYFEPNR KKILDNLDGL LVFVNELGSL FSDSSFSWVD
     TKDYSATEKY SLEQEIVGVG MSKHPLIDIA EKSTQTFTPI SQLVKESEAV VLIQIDSIRI
     IRTKTSGQQM AFLSVNDTKK KLDVTLFPQE YAIYKDQLKE GEFYYLKGRI KERDHRLQMV
     CQQVQMAISQ KYWLLVENHQ FDSQISEILG AFPGTTPVVI HYQKNKETIA LTKIQVHVTE
     NLKEKLRPFV LKTVFR
//

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